海南医学院学报2017，Vol.23Issue(9)：1191-1194,4.DOI:10.13210/j.cnki.jhmu.20170503.002
急性冠脉综合征患者外周血中CCR7表达量与心肌损伤程度、炎症反应程度的相关性
Correlation of the expression of CCR7 in peripheral blood to myocardial injury degree and inflammatory reaction of patients with acute coronary syndrome
摘要
Abstract
Objective: To study the correlation of the expression of CCR7 in peripheral blood to myocardial injury degree and inflammatory reaction of patients with acute coronary syndrome.Methods: stable angina, unstable angina, non ST elevation myocardial infarction and ST elevation myocardial infarction diagnosed in Chengdu Fifth People's Hospital during May 2014-October 2016 were selected as SAP group, UAP group, USTEMI group and STEMI group;healthy volunteers during the same period were selected as control group.The expression of CCR7 in peripheral blood mononuclear cells and the contents of myocardial injury injury and inflammatory response markers in serum were determined.Results: the expression of CCR7 in peripheral blood mononuclear cells and serum IL-1, IL-6, IL-18, MMP2, MMP9 contents of UAP group, USTEMI group, STEMI group were significantly higher than those of SAP group and control group;serum CK-MB, Myo and cTnI contents of USTEMI group, STEMI group were significantly higher than those of UAP group, SAP group and control group;CCR7 in peripheral blood mononuclear cells mRNA expression was positively correlated to serum CK-MB, Myo, cTnI, IL-1, IL-6, IL-18, MMP2, MMP9.Conclusion: the high expression of CCR7 in peripheral blood of patients with acute coronary syndrome can aggravate myocardial injury by activating inflammatory reaction.关键词
急性冠脉综合征/趋化因子受体7/心肌损伤/炎症反应Key words
Acute coronary syndrome/Chemokine receptor 7/Myocardial injury/Inflammatory response分类
医药卫生引用本文复制引用
卿秀..急性冠脉综合征患者外周血中CCR7表达量与心肌损伤程度、炎症反应程度的相关性[J].海南医学院学报,2017,23(9):1191-1194,4.基金项目
四川省卫计委基金项目(30305030139) （30305030139）
Sichuan province Wei Planning Commission fund project (30305030139) （30305030139）
