海南医学院学报2017，Vol.23Issue(9)：1286-1289,4.DOI:10.13210/j.cnki.jhmu.20170421.004
七氟醚预处理联合异丙酚对单肺通气过程中脑氧代谢及炎症反应的影响
Effect of sevoflurane pretreatment combined with propofol on cerebral oxygen metabolism and inflammatory response during one-lung ventilation
摘要
Abstract
Objective: To study the effect of sevoflurane pretreatment combined with propofol on cerebral oxygen metabolism and inflammatory response during one-lung ventilation.Methods: 92 patients who accepted pulmonary lobectomy under one-lung ventilation in Changzheng Hospital Affiliated to Second Military Medical University between August 2014 and March 2016 were selected and divided into sevoflurane group and control group.Before one-lung ventilation (T1), 30 minutes after one-lung ventilation (T2) and 60 minutes after one-lung ventilation (T3), cerebral oxygen metabolism indexes and serum inflammation indexes were determined;after surgical resection, the lung tissue was collected to determine the expression of inflammatory signaling molecules and hypoxia injury molecules.Results: CjvO2 and ajdDCO2 levels as well as serum ICAM-1, IL-1β and TNF-α contents were not significantly different between two groups of patients at T1;CjvO2 levels as well as serum ICAM-1, IL-1β and TNF-α contents of sevoflurane group at T2 and T3 were significantly lower than those of control group while ajdDCO2 levels were significantly higher than those of control group;after surgical resection, TLR4, NF-kB, AQP-4, p38MAPK, HO-1, GLUT-1, HIF-1α and CHOP protein expression in lung tissue of sevoflurane group were significantly lower than those of control group.Conclusion: Sevoflurane pretreatment combined with propofol can improve the cerebral oxygen metabolism and inhibit the inflammatory response during one-lung ventilation.关键词
单肺通气/七氟醚/脑氧代谢/炎症反应Key words
One-lung ventilation/Sevoflurane/Cerebral oxygen metabolism/Inflammatory response分类
医药卫生引用本文复制引用
刘禹利,石学银..七氟醚预处理联合异丙酚对单肺通气过程中脑氧代谢及炎症反应的影响[J].海南医学院学报,2017,23(9):1286-1289,4.基金项目
国家自然科学基金(81372103) （81372103）
National Natural Science Foundation of China (81372103) （81372103）
