杭州师范大学学报（自然科学版）2017，Vol.16Issue(3)：249-254,6.DOI:10.3969/j.issn.1674-232X.2017.03.005
Yap1对少突胶质细胞发育调控的研究
The Analysis of Yap1 in the Development of Oligodendrocytes
摘要
Abstract
Myelin formed by oligodendrocytes in the central nervous system wraps axons to accelerate the conduction of nerve impulses.As a key factor of Hippo pathway,Yap1 involves in the development of multiple organs and types of cells.To investigate the function of Yap1 in oligodendrocyte development,Yap1 was conditionally knocked out in oligodendrocytes,and the phonotypes were checked with in situ hybridization and immunofluorescence.However,the data showed that the early development and differentiation of oligodendrocytes were not affected in mutant mice,which indicated that Yap1 was not required for oligodendrocyte development.关键词
Yap1/Hippo/中枢神经系统/少突胶质细胞Key words
Yap1/Hippo/central nervous system/oligodendrocytes分类
生物科学引用本文复制引用
易敏,杜君卿,黄浩,扈雪梅,邱猛生..Yap1对少突胶质细胞发育调控的研究[J].杭州师范大学学报（自然科学版）,2017,16(3):249-254,6.基金项目
国家自然科学基金项目(31572224,31372150) （31572224,31372150）
国家重点基础研究发展规划项目(2013CB531303). （2013CB531303）
