解放军医学杂志2017，Vol.42Issue(5)：427-431,5.DOI:10.11855/j.issn.0577-7402.2017.05.12
肾移植受者术前甘油三酯代谢对移植肾早期功能恢复的影响
Effects of recipient's pre-transplant triglyceride abnormalities on early renal function recovery after kidney transplantation
摘要
Abstract
Objective To investigate the effect of recipient's pre-transplant triglyceride (TG) abnormalities on early graft function (EGF) after kidney transplantation.Methods According to the inclusion and exclusion criteria,154 identified living-kidney transplant recipients in the 309 Hospital of Chinese PLA from Jan.2011 to Dec.2014 were enrolled in present study,including 124 males and 30 females,and aged of 31.9 ± 8.4 years.The cohort was divided into two groups:TG normal group (0.40＜TG≤1.70mmol/L,n=107) and TG abnormalities group (TG＞l.70mmol/L or require lipid lowering therapy,n=47).The incidences of poor early graft renal function (PEGF),slow graft function (SGF) and delayed graft function (DGF) were compared between the two groups,and then the serum creatinine (Scr) levels were compared among the patients showing immediate graft function (IGF) at 3rd,7th and 30th day after transplantation.The ROC curve was drawn up taking TG as diagnosis index to explore the optimal cut-offvalue for predicting PEGF,SGF and DGF after transplantation.Results Compared with the TG normal group,the TG abnormalities group showed significantly higher incidence of PEGF and DGF (P＜0.05).Among the IGF patients,the TG abnormalities group showed higher Scr level at the 7th and 30th day after transplantation (P＜0.05).The area under ROC curve (AUC) reflected TG levels for PEGF,SGF and DGF were 0.774,0.704 and 0.818,respectively (P＜0.05).The optimal cut-offvalues were all 1.37mmol/L.Conclusions Recipients with abnormal pre-transplant TG level may have worse EGF after renal transplantation.The risk of developing PEGF,S GF and D GF tends to emerge when pre-transplant TG level is higher than 1.37mmol/L.关键词
肾移植/肾功能/高甘油三酯血症/代谢综合征Key words
kidney transplantation/renal function/hypertriglyceridemia/metabolic syndrome分类
医药卫生引用本文复制引用
张大伟,许亮,徐俊楠,詹胜利,李响,袁清,李树欣,蔡明..肾移植受者术前甘油三酯代谢对移植肾早期功能恢复的影响[J].解放军医学杂志,2017,42(5):427-431,5.基金项目
国家自然科学基金(81470043,81570679,81200547) （81470043,81570679,81200547）
首都临床特色应用项目(Z121107001012158) （Z121107001012158）
首都卫生发展科研专项青年基金(首发2016-4-5072) （首发2016-4-5072）
军队青年培育基金(14QNP07)This work was supported by the National Natural Science Foundation of China (81470043,81570679,81200547),the Capital Characteristic Clinic Project (Z121107001012158),the Special Fund for Research on Health Development of the Capital (2016-4-5072),the Army Youth Development Fund (14QNP07) （14QNP07）
