计算机应用研究2017，Vol.34Issue(5)：1303-1307,5.DOI:10.3969/j.issn.1001-3695.2017.05.005
一种基于生物准则的IMRT方案优化方法
Plan optimization method of IMRT based on biological criteria
摘要
Abstract
Aiming at the problem that the physical indices cannot accurately describe the biological response,which is the biological tissues under the non-uniform dose distribution for the plan optimization in the intensity modulated radiation therapy (IMRT),this paper described a new plan optimization method based on biological criteria.At first,the method established the objective function of the plan optimization based on biological criteria according to the dose constraints of various organizations in the patient's.Then,it adopted the L-BFGS-B algorithm to solve the optimization problem.Experimented results show that,on the premise of guarantee the target dose coverage,compared with the plan optimization method based on physical criterion,the proposed method reduced the NTCP by 6.86％.Furthermore,the NTCP of the result optimized by the proposed method decreased by 1.30％ compared with the method for solving the optimization problem by using the L-BFGS algorithm.The results show that the introduction of the biological factors into the plan optimization can reflects the biological effects more accurately.And using the L-BFGS-B algorithm can solve the problems of the plan optimization more quickly and accurately.关键词
调强放射治疗/生物准则/L-BFGS-B/肿瘤控制率/正常组织并发症概率Key words
IMRT/biological criteria/L-BFGS-B/TCP/NTCP分类
信息技术与安全科学引用本文复制引用
张丽媛,张鹏程,桂志国,舒华忠,杨婕..一种基于生物准则的IMRT方案优化方法[J].计算机应用研究,2017,34(5):1303-1307,5.基金项目
国家自然科学基金资助项目(61271357) （61271357）
山西省自然科学基金资助项目(2015011046) （2015011046）
中北大学2013年较科学基金计划资助项目 （）
