实用临床医药杂志2017，Vol.21Issue(9)：52-56,5.DOI:10.7619/jcmp.201709014
内镜黏膜下剥离术治疗早期胃癌及高级别上皮内瘤变的疗效分析
Efficacy of endoscopic submucosal dissection in the treatment of early gastric canceRand high-grade intraepithelial neoplasia
摘要
Abstract
Objective To investigate value of endoscopic submucosal dissection foRearly gastric canceR(EGC) and high-grade intraepithelial neoplasia (HGIN) using endoscopic submucosal dissection (ESD) and its risk factors influencing dissection.Methods The date of 80 patients who underwent ESD foREGC and HGIN in ouRhospital from DecembeR2012 to June 2014 were retrospectively reviewed.The clinical manifestation,endoscopic appearance and histopathological information were collected and the risk factors influencing curative resection afteRESD were analyzed.Results Among the enrolled 80 patients,the overall resection rate was 100%,the complete resection rate was 86.25% and the curative resection rate was 86.25%.The curative resection rate of the EGC group was significantly less than that of the HGIN group,(93.6% vs.75.76%,P<0.05).Single factoRanalysis revealed that patients with the following criteria were more likely to have higheRresection rate:a lesion size ≥2 cm,submucosa invasion and ulceration (P<0.05).Additional multivariate regression analysis demonstrated that submucosa invasion (OR=6.300,95% CI: 0.516-12.658,P<0.001),a lesion size ≥2 cm(OR=12.193,95% CI: 1.323～112.347,P=0.027) and ulceration(OR=5.679,95% CI: 1.087～29.678,P=0.040)were independent risk factors foRresection.Conclusion ESD is effective method foREGC and HGIN patients.Strictly evaluation and comprehensive treatment method are necessary foRsubmucosa invasion,lesion size ≥2 cm,and ulceration patients.关键词
早期胃癌/胃黏膜高级别上皮内瘤变/内镜黏膜下剥离术/治愈性切除/随访Key words
early gastric cancer/high-grade intraepithelial neoplasia of gastric mucosa/endoscopic submucosal dissection/curative resection/follow up分类
医药卫生引用本文复制引用
张海涵,蒋建霞..内镜黏膜下剥离术治疗早期胃癌及高级别上皮内瘤变的疗效分析[J].实用临床医药杂志,2017,21(9):52-56,5.基金项目
江苏省六大人才高峰课题基金资助项目(2015-WSN-028) （2015-WSN-028）
