检验医学与临床2017，Vol.14Issue(11)：1602-1604,3.DOI:10.3969/j.issn.1672-9455.2017.11.030
耐碳青霉烯类铜绿假单胞菌的耐药机制
Drug resistance mechanism of carbapenem-resistant Pseudomonas aeruginosa
袁翊 1叶帮芬 1万小涛 1钟方财 1黄波1
作者信息
- 1. 四川省内江市第一人民医院检验科 641000
- 折叠
摘要
Abstract
Objective To investigate the drug resistance mechanism of carbapenem-resistant Pseudomonas aeruginosa in this hospital.Methods The bacterial identification and drug susceptibility testing were performed by ATB Expression.Drug resistance genes of IMP,VIM and outer membrance protein gene OprD2 in all the strains were detected by PCR.Results The resistance rate of 70 strains of carbapenem-resistant Pseudomonas to polymyxin,amikacin,gentamicin,ceftazidime,cefepime and ciprofloxacin were 1.4%,47.1%,65.7%,64.3%,60.3% and 71.4%,respectively.Of all the strains,30 stains(42.9%) were IMP gene positive,13 stains(17.6%) were VIM positive,70 stains(100.0%) were OprD2 deletion.Conclusion The situation of multiple drug resistance of carbapenem-resistant Pseudomonas aeruginosa is serious.The loss of outer membrance protein gene OprD2 may be the main mechanism of carbapenem-resistantce of Pseudomonas aeruginosa.关键词
铜绿假单胞菌/碳青霉烯类/耐药基因Key words
Pseudomonas aeruginosa/carbapenems/resistance genes引用本文复制引用
袁翊,叶帮芬,万小涛,钟方财,黄波..耐碳青霉烯类铜绿假单胞菌的耐药机制[J].检验医学与临床,2017,14(11):1602-1604,3.
