河南科技大学学报（医学版）2017，Vol.35Issue(2)：88-91,4.DOI:10.15926/j.cnki.issn1672-688x.2017.02.003
抑癌基因p53、PTEN与子宫内膜癌预后相关性分析
Correlation Analysis between P53, PTEN and Endometrial Carcinoma Prognosis Factors
王文翔 1钟兰 2杨开选 3彭芝兰2
作者信息
- 1. 新乡市中心医院妇瘤一科,河南新乡 453000
- 2. 四川大学华西第二医院妇产科,四川成都 640001
- 3. 四川大学华西第二医院病理科,四川成都 640001
- 折叠
摘要
Abstract
Objective To study the relationship between p53 and PTEN and clinicopathological characteristics and prognosis of endometrial carcinoma.Methods The clinical and pathological data of 99 patients with endometrial carcinoma were retrospectively analyzed, and the risk factors were classified according to the prognostic factors.The expression of p53 and PTEN in tissues was detected by immunohistochemistry, and the correlation between the expression of p53, PTEN and clinicopathological features and survival rate was analyzed.Results There was significant difference in the overexpression of p53 protein in surgical-pathologic staging (P=0.028).The overexpression of p53 protein was associated with the survival rate on type I endometrial carcinoma, G1+ G2 grade, Ⅰ+ Ⅱ stage, and no metastatic patients.Univariate analysis Log-rank test results showed that histological type and grade, surgical-pathologic stage, lymph node metastasis were associated with survival rate, p53 protein positive overexpression has low survival rate.Pathological staging and p53 protein overexpression were independent prognostic factors of en-dometrial cancer by Cox′s proportional hazard regression model.The expression of PTEN was absent in the later stage and higher grade, and the expression of PTEN was not correlated with histological grade and stage,pathological type and lymph node metastasis.While the loss of PTEN expression was not associated with overexpression of p53 protein(P>0.05).Conclusion p53 protein overexpression was an independent prognostic factor of endometrial carcinoma.The typeⅠendometrial carcinoma, G1+ G2 grade, Ⅰ+ Ⅱ stage, no lymph node metastasis with p53 protein overexpression had lower survival rate.PTEN expression was absent in the worse differentiation and clinical staging, and it was not related to the survival rate in the patients.关键词
子宫内膜癌/p53/PTEN/免疫组化/预后Key words
endometrial carcinoma/p53/PTEN gene/immunohistochemistry/prognosis分类
医药卫生引用本文复制引用
王文翔,钟兰,杨开选,彭芝兰..抑癌基因p53、PTEN与子宫内膜癌预后相关性分析[J].河南科技大学学报（医学版）,2017,35(2):88-91,4.
