国际眼科杂志2017，Vol.17Issue(7)：1313-1316,4.DOI:10.3980/j.issn.1672-5123.2017.7.29
TransPRK治疗中高度近视术中使用低浓度MMC预防haze的疗效
Efficacy and safety of low dose MMC to prevent haze in TransPRK with moderate and high myopia
摘要
Abstract
AIM: To investigate the efficacy and safety of low dose mitomycin C (MMC) to prevent haze in trans photorefractive keratectomy (TransPRK) with moderate and high myopia, and to observe the changes of corneal density.METHODS: Sixty-one patients underwent TransPRK with moderate and high myopia.Eyes were divided into research group (0.1g/L MMC for 40s) and control group(0.2g/L MMC for 40s) randomly.There were 21 patients in research group and 40 patients in control group.Cornea epithelial healing time, pain score, visual acuity, manifest refraction, haze and cornea density were analyzed.RESULTS: The epithelial healing time (0.1g/L group: 3.86±1.11d, 0.2g/L group: 4.23±1.27d) and pain score (0.1g/L group: 2.01±0.58, 0.2g/L group: 1.79±0.7) were no significant difference between two groups(P=0.667, P=0.582).It was similar in spherical equivalent at 1mo and 3mo post-operation(0.1g/L group: 0.28±0.25, 0.05±0.23D;0.2g/L group:-0.13±0.17, 0.07±0.22D;P=0.178, P=0.490).The BCVA of control group decreased at 1mo and improved to the same level as pre-operation at 3mo(F=15.847, P<0.001);0.1g/L group showed the same trend, but the changes were no significant difference(F=3.038, P=0.093).There were also no significant difference in Haze between two groups post-operation(z=-0.709, P=0.479;z=-0.478, P=0.633).The change of cornea density was matched with the BCVA (0.1g/L group F=27.399, P=0.001;0.2g/L group F=8.313, P=0.001)and it was similar between two groups.CONCLUSION: The using of low dose MMC to prevent haze in TransPRK with moderate and high myopia is safe and effective.It is therapeutic equivalence to regular dose (0.2g/L).Besides the slit lamp, we can use the corneal density to measure the corneal transparency.关键词
经上皮准分子激光角膜切削术/丝裂霉素C/角膜上皮下雾状混浊Key words
trans photorefractive keratectomy/mitomycin C/haze引用本文复制引用
李瑾瑜,张日平,孙丽霞,王贤,刘彩霞..TransPRK治疗中高度近视术中使用低浓度MMC预防haze的疗效[J].国际眼科杂志,2017,17(7):1313-1316,4.基金项目
广东省医学科学研究基金(No.B2014291) （No.B2014291）
Medical Science Research Foundation of Guangdong Province (No.B2014291) （No.B2014291）
