药学研究2017，Vol.36Issue(6)：337-340,4.DOI:10.13506/j.cnki.jpr.2017.06.008
米屈肼胶囊在中国健康受试者中药代动力学的研究
Pharmacokinetic research of Mildronate Capsule in healthy Chinese subjects
于丽燕 1孙荣梅 1冉桂梅 1相秉仁1
作者信息
- 1. 中国药科大学工学院,江苏 南京 211198
- 折叠
摘要
Abstract
Objective To study the pharmacokinetics of Mildronate Capsules in healthy subjects in a single and multiple dose.Methods Using multi-dose of single-sequence for drug design,12 healthy subjects were respectively numbered according to the weight from heavy to light order number,all the female volunteers were behind the male volunteers.All the volunteers were given the low doses of 250 mg (250 mg/pill×1) medicine.After cleaning period all the volunteers were given the high doses of 1 000 mg (500 mg/pill×2) medicine;Again after cleaning period all the volunteers were given the dose 500 mg (500 mg/pill×1) medicine,and then all the volunteers were given the middle-dose of this medicine(oral drug 6 days in a row,oral this medicine twice a day from the first day to the fifth day,oral the medicine once time in the morning of the sixth day,every time the dose was 500 mg).Results The pharmacokinetic characteristics of mildronate were non-linear pharmacokinrtics in human body.The t1/2 was prolonged with increasing does,the result of multiple dose indicated the occurrence of accumulation in the multidoses.Conclusion The method developed in this study was suitable for the pharmacokinetic study of mildronate.关键词
米屈肼/高效液相色谱-质谱/血药浓度/药动学Key words
Mildronate/HPLC-MS/MS/Plasma concentration/Pharmacokinetics分类
医药卫生引用本文复制引用
于丽燕,孙荣梅,冉桂梅,相秉仁..米屈肼胶囊在中国健康受试者中药代动力学的研究[J].药学研究,2017,36(6):337-340,4.
