药学研究2017，Vol.36Issue(6)：344-346,372,4.DOI:10.13506/j.cnki.jpr.2017.06.010
低氧诱导因子抑制剂的研究进展
Advances in the research and development of HIF-1 inhibitors
摘要
Abstract
Hypoxia-inducible factor (HIF) is an essential transcription factor,which mediates a hypoxic response at decreased oxygen tensions.HIF plays vital roles in tumor development and progression and meditates tumor resistance to chemotherapy and radiotherapy and is associated with poor prognosis in cancer patients.Therefore,research and development of HIF inhibitors has the potential to improve treatment efficacy.In this article,three ways of targeting HIF-1 were summarized so as to lay the foundation for the therapeutic use of HIF inhibitors.关键词
低氧诱导因子/缺氧/转录因子/抑制剂/抗肿瘤Key words
HIF/Hypoxia/Transcription factor/Inhibitor/Anti-tumor分类
医药卫生引用本文复制引用
丁凯强,田薇,周德旺,冯爽,杨勇..低氧诱导因子抑制剂的研究进展[J].药学研究,2017,36(6):344-346,372,4.基金项目
国家自然科学基金青年基金项目(No.81502407) （No.81502407）
国家自然科学基金(No.81403020) （No.81403020）
江苏省自然科学基金青年基金项目(No.BK20140666) （No.BK20140666）
