药学研究2017，Vol.36Issue(6)：347-352,6.DOI:10.13506/j.cnki.jpr.2017.06.011
小分子化合物对PKM2作用机制的研究进展
Research progress in the mechanism of action of small molecular compounds on PKM2
摘要
Abstract
Pyruvate kinase M2(PKM2) may play an important role in regulating the glucolysis,proliferation and signal transduction of tumor cells.The constantly deepened researches in this field will endow the development of the new targets of anticancer drugs with bright prospect for the therapy of clinical.By the method of literature summary,the present paper,discusses the mechanism that the small molecule compounds modulate the expression regulation,inhibition and excitation of PKM2 and puts forward to be an important research direction in the anti-tumor drug screening.关键词
M2型丙酮酸激酶/作用机制/小分子化合物Key words
Pyruvate kinase M2/The mechanism of action/Small molecular compounds分类
医药卫生引用本文复制引用
於怀龙,余嘉莹,张景红..小分子化合物对PKM2作用机制的研究进展[J].药学研究,2017,36(6):347-352,6.基金项目
国家基金面上项目(No.81173503) （No.81173503）
华侨大学人才启动项目(No.BS105) （No.BS105）
华侨大学基本科研业务费专项基金(No.JB-ZR1134) （No.JB-ZR1134）
研究生科研创新能力培育项目 （）
