血清miR-146a作为脓毒症诊断标记物的研究OA北大核心CSTPCD
Serum miR-146a as potential biomarker for sepsis
目的:探讨miR-146a在脓毒症患者血清中的表达及诊断价值.方法:采集98例一般脓毒症患者、69例重症脓毒症患者及30例健康人血清,检测miR-146a的表达,ROC曲线分析miR-146a在脓毒症中的诊断意义.结果:miR-146a在健康组、一般脓毒症组与重症脓毒症组中的表达依次降低,ROC曲线分析表明miR-146a诊断脓毒症的曲线下面积为0.983,当miR-146a为0.805时诊断脓毒症的敏感度和特异性分别为0.967和0.940;其…查看全部>>
Objective To study the expression of miR-146a in the serum of sepsis and the diagnostic value.Methods Serum miR-146a expression was detected in 98 patients diagnosed with sepsis,69 patients with severe sepsis and 30 healthy controls.ROC plots were used to evaluate the diagnostic value.Results The expression of miR-146a was decreased successively in healthy group,general sepsis group and severe sepsis group.In the diagnosis of sepsis,at the optimal expr…查看全部>>
刘旭辉;王韧;张献玲;叶志强
510630 广州市,中山大学附属第三医院急诊科510630 广州市,中山大学附属第三医院麻醉科510630 广州市,中山大学附属第三医院肝脏外科510630 广州市,中山大学附属第三医院急诊科
脓毒症miR-146a诊断
SepsismiR-146aDiagnosis
《实用医学杂志》 2017 (7)
1103-1105,3
广东省科技计划项目(编号:2014A020212533)
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