实用医学杂志2017，Vol.33Issue(8)：1231-1234,4.DOI:10.3969/j.issn.1006-5725.2017.08.010
辣椒素预防吲哚美辛致急性胃黏膜损伤的作用及机制
The effect and mechanism of capsaicin prevented acute gastric mucosal injury by indomethacin
摘要
Abstract
Objective The study of capsaicin (CAP) on the effect and mechanism of indomethacin induced acute gastric mucosal injury in different period.Methods 80 SD rats were randomly divided into 8 groups with 10 rats in each group.The experiment was completed in two phases,and the Ⅰ period was 2 weeks,the Ⅱ period was 4 weeks.The Ⅰ period including group A1 (control group),group B1 (model group),group C1 (CAP group),group D1 (CAP + indomethacin group).The grouping method of the two periods were the same.The rats' gastric mucosa were damaged by indomethacin,and then killed the rats 4 hours later.Last,astric juice was collected to determine the total acidity of gastric acid,counted thegastric mucosal injury index,observed the gastric mucosa pathological injury,detected the expression of TRPV 1、CGRP、MDA、SOD and PGI2.Results The Ⅰ period:the gastric mucosa of group A1 and C1 had no damage.Group D1 compared with group B1,there was no significant difference in gastric mucosa injury (P ＞ 0.05),total acidity decreased significantly (P ＜ 0.05),MDA was no significant difference (P ＞ 0.05),SOD、PGI2 increased significantly (P ＜ 0.05),the expression of TRPV1、CGRP increased significantly (P ＜ 0.05).The Ⅱperiod:the gastric mucosa of group A2 and C2 had no damage.Group D2 compared with group B2,the gastric mucosa injury were significantly reduced (P ＜ 0.05),total acidity decreased significantly (P ＜ 0.05),MDA decreased significantly (P ＜ 0.05),SOD、PGI2 increased significantly (P ＜ 0.05),the expression of TRPV1、CGRP increased significantly (P ＜ 0.05).Conclusion There was no damage to the general morphology and histology of gastricmucosa in rats by intragastric CAP 1 mg/(kg· d) for 2 weeks and 4 weeks.2.It could prevent that indomethacininduced acute gastric mucosal injury in rats by pretreated with CAP 1 mg(kg· d) for 4weeks.关键词
辣椒素/吲哚美辛/胃黏膜损伤/TRPV1/CGRPKey words
CAP/Indomethacin/Gastric mucosal injury/TRPV1/CGRP引用本文复制引用
阳凤,王瑶,钟武,刘济滔,尹德锋,彭燕..辣椒素预防吲哚美辛致急性胃黏膜损伤的作用及机制[J].实用医学杂志,2017,33(8):1231-1234,4.基金项目
四川省科技厅课题(编号:12037) （编号:12037）
