实用医学杂志2017，Vol.33Issue(8)：1239-1243,5.DOI:10.3969/j.issn.1006-5725.2017.08.012
牙周炎与牙周治疗对肥胖大鼠胰岛素抵抗作用的影响
A preliminary study of mechanism of periodontitis and periodontal therapy influence in insulin resistance for obesity rats
摘要
Abstract
Objective To explore the mechanism of the experimental periodontitis and initial periodontal therapy on insulin resistance of obese rats associated with periodontitis.Methods Blood samples were collected from SD rats of obese group,periodontitis associated with obese group,periodontal therapy group and control group.Body index,data about insulin resistance and Observed pathological changes were calculated.Results Comparison of four groups:more severe insulin resistance and islet structural dysfunction was observed in obesity with periodontitis group than that of group with obesity alone.After periodontal therapy,inflammation and insulin resistance may be improved.Results from pathological specimens also supported this result.Conclusions The periodontitis with obesity can enhance the inflammatory state of obesity and cause the deterioration of insulin resistance.The initial periodontal treatment can relieve the inflammation of obesity with periodontitis and improve the resistance of insulin.It may be the reason of insulin resistance when obesity with periodontitis that the signaling pathways of IRS-1 and IRS-2 blocked,and PDX-1,GK,GLUT and other protein expression inhibited.关键词
牙周炎/肥胖/牙周治疗/胰岛素受体底物Key words
Periodontitis/Obesity/Periodontal treatment/Insulin receptor substrates引用本文复制引用
柴巧学,钟素兰,倪佳,周磊,陈蕾,章锦才..牙周炎与牙周治疗对肥胖大鼠胰岛素抵抗作用的影响[J].实用医学杂志,2017,33(8):1239-1243,5.基金项目
国家自然科学基金项目资助项目(编号:81300890) （编号:81300890）
广东省医学科学技术研究基金(编号:A2014110) （编号:A2014110）
