实用医学杂志2017，Vol.33Issue(8)：1320-1323,4.DOI:10.3969/j.issn.1006-5725.2017.08.033
不同的腹腔热灌注化疗药物治疗晚期卵巢癌临床分析
Clinical analysis of different intraperitoneal hyperthermic chemotherapy drugs in the treatment of advanced ovarian cancer
摘要
Abstract
Objective To explore short term curative effects and adverse reactions of two different kinds of intraperitoneal hyperthermic chemotherapy (IPHC) drugs in the treatment of advanced ovarian cancer after cytoreductive surgery.Methods 76 patients with advanced ovarian cancer in the Second Affiliated Hospital of Zhengzhou University from July 2013 to November 2015 were divided into two groups:single-drugs group of 36 patients (IPHC with 5-fluorouracil after cytoreductive surgery combined with intravenous chemotherapy),combined treatment group of 40 patients(IPHC with 5-fluorouracil and carboplatin after cytoreductive surgery combined with intravenous chemotherapy).Short term curative effects,postoperative clinical indicators and adverse reactions of chemotherapy in two groups were compared and analyzed.Results The CA125 effective rates in single-drugs and combined treatment group were 86.11％ and 95％,and the difference showed statistically significant differences (P ＞ 0.05).The ascites remission rates in single-drugs and combined treatment group were 97.22％ and 97.5％,and the difference between two groups showed no statistically significant differences (P ＞ 0.05).Adverse drug reactions showed statistical difference in distribution of the bone marrow,liver damage and gastrointestinal toxicity.No statistical difference were found between the two groups in terms of distribution of renal damage and cardiovascular system damage.Conclusion IPHC after cytoreductive surgery in the treatment of advanced ovarian cancer is an effective means as adjuvant chemotherapy.The short-term curative effect of combined treatment group is obvious and adverse reactions can be tolerated.IPHC can be applied according to the patient's specific clinical situation.关键词
腹腔热灌注化疗/晚期卵巢癌/5-氟尿嘧啶/卡铂Key words
Intraperitoneal hyperthermic chemotherapy/Advanced ovarian cancer/5-fluorouracil/Carboplatin引用本文复制引用
赵月明,黄冬梅,孙欣欣..不同的腹腔热灌注化疗药物治疗晚期卵巢癌临床分析[J].实用医学杂志,2017,33(8):1320-1323,4.基金项目
河南省科学技术发展计划项目(编号:112102310505) （编号:112102310505）
