介孔二氧化硅纳米粒作为中药控释和靶向载体在肿瘤治疗中的应用进展OACSTPCD
Development of mesoporous silica-based nanoparticles with controlled releaseand targeted release capability for cancer therapy with traditional Chinese medicine
介孔二氧化硅因具有有序介孔结构、比表面积大、生物相容性好及表面易于修饰等特点,在生物医药等领域显示出了极大的应用前景.文章主要专注于介孔二氧化硅纳米粒子的发展,主要讨论了药物的可控释放和靶向修饰.通过修饰介孔二氧化硅纳米颗粒(MSNs)使其具有刺激响应的特性实现可控释药,内部刺激响应主要包括,pH响应、氧化-还原响应和生物分子响应等;外部刺激主要包括磁、光等.同时详细介绍了多功能化介孔二氧化硅纳米粒.对目前介孔二氧化硅基药物输送体系在实际应用中存…查看全部>>
Mesoporous silica materials have attracted much attention for their potential biomedical applications due to their tailored mesoporous structure, large surface area, good biocompatibility, and the ease of surface functionalization. In this review, we focus on the development of mesoporous silica based nanoparticles, as this type of materials provides a relatively stable material that is amenable to various chemical modifications.We provide an ove…查看全部>>
李楠;刘岩;郭盼;黄瑞;刘志东
天津中医药大学,天津 300193天津工业大学,天津 300387天津中医药大学,天津 300193天津中医药大学,天津 300193天津中医药大学,天津 300193
医药卫生
二氧化硅纳米粒肿瘤靶向载体
mesoporous silica-based nanopartidescancertargeted
《天津中医药大学学报》 2017 (3)
OX26/ApoE共修饰脑靶向载黄连解毒汤介孔硅纳米载体的构建及治疗脑缺血再灌注损伤的PK/PD研究
161-166,6
国家自然科学基金资助(81673605).
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