天然产物研究与开发2017，Vol.29Issue(5)：731-734,4.DOI:10.16333/j.1001-6880.2017.5.002
多刺绿绒蒿中的一个新生物碱类化合物
A New Alkaloid from Meconopsis horridula
摘要
Abstract
Meconopsis horridula is an important traditional Tibetan folk medicine.The plant has function of clearing internal heat and promoting blood circulation for removing blood stasis.It was used to treat fractures and bruises.Many alkaloids have been isolated from this species,most of which have significant bioactivities.In this study,the 95％ alcohol extract from the aerial part of Meconopsis horridula was fractionated using open column chromatography with silica gel and ODS.Three alkaloids were isolated from the plant.A new proaorphine alkaloid,(6a-S)-des-N-methyl-(+)-cryprochine (1),together with two known alkaloids,cheilanthifoline (2) and protopine (3) were isolated and identified.Compound 2 was isolated from this plant for the first time.The structures of purified compounds were determined using spectroscopic methods including IR,MS,and 1D and 2D NMR,and by comparison with literature data for known alkaloids.关键词
藏药/多刺绿绒蒿/生物碱/(6a-S)-des-N-methyl-(+)-cryprochineKey words
Tibetan medicine/Meconopsis horridula/alkaloid/(6a-S)-des-N-methyl-(+)-cryprochine分类
医药卫生引用本文复制引用
常颜,王晓玲,唐晓莹,袁绿益,陈炼红..多刺绿绒蒿中的一个新生物碱类化合物[J].天然产物研究与开发,2017,29(5):731-734,4.基金项目
Graduate student innovative research project of Southwest University for Nationalities (CX2015SZ046) （CX2015SZ046）
Fundamental Research Funds for the Central Universities of China(2016NFWMZ02) （2016NFWMZ02）
