天然产物研究与开发2017，Vol.29Issue(5)：762-766,5.DOI:10.16333/j.1001-6880.2017.5.007
阿魏酸对阿尔茨海默病转基因小鼠脑内氧化应激和凋亡相关蛋白的影响
Effects of Ferulic Acid on Oxidative Stress and Apoptosis Related Proteins in Alzheimer's Disease Transgenic Mice
摘要
Abstract
In this study,the effects of ferulic acid on oxidative stress and apoptosis related proteins in the APP/PS1 transgenic mice brain were investigated.Western blot and Real-Time PCR methods were used to detect the expression of apoptosis related proteins in brains of the WT mice,APP/PS1 transgenic mice and different concentrations of ferulic acid treatment mice,and SOD activity and MDA content were detected in mice brain of each group.The activity of SOD increased compared to the AD model mice,and the content of MDA reduced after ferulic acid treatment,the concentration of ferulic acid in treatment group was the most obvious;The expression of p-JNK,p-C-Jun,Caspase-3,Bax and Bcl-2 was increased compared to those of the WT mice,the hyperphosphorylation proteins were significantly reduced after ferulic acid treatment,the concentration of ferulic acid in treatment group was the most obvious.These results indicated that ferulic acid can decrease oxidative stress effect in AD mice brain through its powerful antioxidant activity,and decline the level of apoptosis related proteins in AD mice brain.These results prompted that ferulic acid had important theoretical significance in the clinical treatment of AD.关键词
阿魏酸/APP/PS1转基因小鼠/凋亡/氧化应激Key words
ferulic acid/APP/PS1 transgenic mice/apoptosis/oxidative stress分类
医药卫生引用本文复制引用
王玥,王旭,于嵩,王淳..阿魏酸对阿尔茨海默病转基因小鼠脑内氧化应激和凋亡相关蛋白的影响[J].天然产物研究与开发,2017,29(5):762-766,5.基金项目
国家自然科学基金(81373718) （81373718）
