天然产物研究与开发2017，Vol.29Issue(5)：774-782,9.DOI:10.16333/j.1001-6880.2017.5.009
广藿香不同药用部位挥发油物质基础差异与抗白色念珠菌的相关性研究
Composition Differences of Volatile Oil from Different Parts of Pogostemon cablin and Its Correlation with Anti-fungus Activity Against Candia Albicans
摘要
Abstract
To elucidate the differences of material base of volatile oils from the leaves,aerial parts and whole part of Pogostemonis herba and its correlation with anti-Candida albicans activity.The fingerprints of volatile oils were established by GC-MS.The common peaks of the three oils were relatively recognized and cluster analyzed by SPSS software to compare the fingerprint similarity and analyze of material differences.The anti-C.albicans activity was detected by double dilution method and the correlation with fingerprint was identified by grey relational analysis.The cluster analysis of the other two oils was found to be divided into the same categories and the similarities were perfectly correlated,except for the oil of leaves.Comparing with the aerial part,the whole plants had almost no change in the types and contents of the components except the drastically enhancing of patchoulenone.The oil of leaves contained no patchoulenone.The efficacy order of anti-C.albicanswas as follows:the oil of whole part ＞ the oil of aerial parts ＞ the oil of leaves,and patchoulenone had the highest correlation with anti-C.albicans activity.In conclusion,the use of the whole plant instead of the aerial parts of P.cablin did not change the original components of the volatile oil,but increased the patchoulenone content.Furthermore,it also improved the effect of anti-C.albicans effect.关键词
广藿香油/不同药用部位/GC-MS/广藿香酮/抗白色念珠菌Key words
patchouli oil/different medicinal parts/GC-MS/patchoulenone/anti-Candidaalbicans分类
医药卫生引用本文复制引用
王振强,赵思蕾,余佳丽,林美斯,唐晓章,曹科,林大胜..广藿香不同药用部位挥发油物质基础差异与抗白色念珠菌的相关性研究[J].天然产物研究与开发,2017,29(5):774-782,9.基金项目
四川省重大产业技术创新项目(2015PT024) （2015PT024）
四川省科技支撑计划(2011SZ0318) （2011SZ0318）
