天然产物研究与开发2017，Vol.29Issue(5)：783-786,4.DOI:10.16333/j.1001-6880.2017.5.010
芽孢杆菌HZ16发酵产物中的环二肽类化学成分
Cyclodipeptides from Bacillus sp.HZ16
摘要
Abstract
To study the chemical constituents from Bacillus HZ16.The compounds were isolated and purified by means of chromatographic techniques and their structures were identified on the basis of spectral features.8cyclic dipeptides,named Cordycedipeptide A (1),(2E/Z,5Z)-2-[(4-methoxyphenyl) methylene]-5-(2-methylpropylidene)-3,6-piperazinedione (2),Cyclo (Tyr-Pro) (3),Cyclo (Pro-Val) (4),Cyclo (Thr-Leu) (5),Cyclo (Pro-Thr) (6),Cyclo (Dehydroala-Leu) (7) and Cyclo(4-OH-Pro-Leu) (8),were isolated from the organic extract of fermentation broths of Bacillus HZ16.These 8 compounds wereisolated from Bacillus sp.for the first time and compouds 1,2,3 and 8 showed significant cytotoxic activity against the brine shrimp larvae,the mortality rate in 4 h were 96.3％,89.2％,96.8％ and 99.5％,respectively.关键词
芽孢杆菌/环二肽/细胞毒活性Key words
Bacillus/cyclodipeptide/cytotoxicity分类
生物科学引用本文复制引用
王宏鹏,楼坚,陈丽春,李音,班兆军,黄俊..芽孢杆菌HZ16发酵产物中的环二肽类化学成分[J].天然产物研究与开发,2017,29(5):783-786,4.基金项目
浙江省农业生物资源生化制造协同创新中心开放基金项目(2016KF0025,2016KF0003,2016KF0007) （2016KF0025,2016KF0003,2016KF0007）
浙江省科技计划项目(2016C37078) （2016C37078）
