天然产物研究与开发2017，Vol.29Issue(5)：856-861,6.DOI:10.16333/j.1001-6880.2017.5.024
正交实验优化川陈皮素微乳凝胶剂促渗剂及体外释药评价
Optimization of Penetration Enhancer of Nabiletin Micromulision Gel by Orthogonal Test and Evaluation of Drug Release in vitro
袁旭 1刘新 2郝旺青 1高倩 2林於1
作者信息
- 1. 重庆医科大学中医药学院,重庆400016
- 2. 重庆医科大学药学院,重庆400016
- 折叠
摘要
Abstract
The penetration enhancer of nabiletin micromulision gel was optimized and its drug release mechanism in vitro was studied.Orthogonal design was employed to transdermal diffusion test in nasal mucosa of rabbits in vitro,the cumulative permeation quantity and permeation rate of nabiletin were used as indexes to optimize the prescription;Behavior of drug release was studied by modifying diffusion cell and mechanism of drug release was studied by membrane-less model.The results showed that the influence order of different penetration enhancers on cumulative permeation quantity and permeation rate of nabiletin were as follows:azone ＞ borneol ＞ propanediol,while azone had significant influence (P ＜0.05),and the cumulative release rate of microemulsion gel in 12 hours was 86％ which followed the Higuchi equation,erosion rate of microemulsion gel was low and not linearly correlated with the drug release rate(r =0.9387).It was evidently that the prescription of 2％ azone,2％ borneol and 1％ propanediol can be used as the compound penetration enhancer,it had a good property of drug release in vitro and showed controlled release property.关键词
川陈皮素/微乳凝胶剂/正交实验/促渗剂Key words
nobiletin/microemulsion gel/orthogonal test/penetration enhancer分类
医药卫生引用本文复制引用
袁旭,刘新,郝旺青,高倩,林於..正交实验优化川陈皮素微乳凝胶剂促渗剂及体外释药评价[J].天然产物研究与开发,2017,29(5):856-861,6.
