现代医院2017，Vol.17Issue(5)：710-712,715,4.DOI:10.3969/j.issn.1671-332X.2017.05.026
Netrin-1促进脑缺血康复的作用机制研究
Study of NT-1 in Promoting the Recovery Mechanism in MCAO Model
罗春云 1贺小松2
作者信息
- 1. 广州医科大学附属第四医院 广东广州 511447
- 2. 广州医科大学人体解剖教研室 广东广州 511436
- 折叠
摘要
Abstract
Objective To explore the study of NT-1 promote recovery mechanisms after cerebral ischemia.Methods 30 ICR mice were equally divided into NT-1 and BSA groups and respectively given NT-1 and BSA injection in the brain.The middle cerebral artery ischemia model was established with suture method.NRSS score and beam-walking test were used to exam the behavior performance after MCAO.Immnuohischemstry was used to evaluate the status of angiogenesis and apoptosis.Results Compared to the BSA group, NT-1 not only reduced the time on the beam-walking but the score of NRSS behavioristices.NT-1 also increased the number of vessels and reduced the number of apoptotic cells.Conclusion NT-1 cerebral injection can promote the recovery by increasing angiogenesis and inhibiting apoptosis.NT-1 is a promise target in the treatment of cerebral ischemia.关键词
NT-1/脑缺血/血管新生/凋亡Key words
NT-1/Cerebral Ischemia/Cerebral Occlusion/Angiogenesis/Apoptosis分类
医药卫生引用本文复制引用
罗春云,贺小松..Netrin-1促进脑缺血康复的作用机制研究[J].现代医院,2017,17(5):710-712,715,4.
