现代医院2017，Vol.17Issue(5)：752-754,3.DOI:10.3969/j.issn.1671-332X.2017.05.041
右美托咪啶对体外循环下心内直视手术患者的心肌保护作用
Myocardial Protection Effect of Dexmedetomidine in Patients Undergoing Open-heart Surgery under CPB
曾秋谷 1黎达锋 1岑相如 1杨奕尤 1陈显琴 1林保留 1谭月仙1
作者信息
摘要
Abstract
Objective To observe the myocardial protective effect of dexmedetomidine in patients undergoing open-heart surgery under cardiopulmonary bypass (CPB).Methods 50 patients of open-heart surgery under CPB were randomly divided into two groups equally, namely observation group and control group.Observation group was treated with injection of dexmedetomidine at 0.5 μg/kg for 15 min, and then maintained at 0.4 μg/kgoh.The control group was given equal volume of normal saline.Concentrations of IMA and cTnI were determined before anaesthesia (t0), after 30 minutes of CPB (t1) and after surgery (t2).Results IMA and cTnI concentrations of t1 and t2 in the observation group were significantly lower than those in the control group (P<0.05).Conclusion Dexmedetomidine has obvious protective effect on myocardium, which can reduce open-heart surgery of patients with myocardial ischemia reperfusion injury (MIRI).关键词
右美托咪啶/心内直视手术/心肌保护Key words
Dexmedetomidine/Open-heart Surgery/Myocardial Protection分类
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曾秋谷,黎达锋,岑相如,杨奕尤,陈显琴,林保留,谭月仙..右美托咪啶对体外循环下心内直视手术患者的心肌保护作用[J].现代医院,2017,17(5):752-754,3.
