协和医学杂志2017，Vol.8Issue(2)：161-166,6.DOI:10.3969/j.issn.1674-9081.2017.03.015
HIV阴性结核分枝杆菌血流感染成年患者临床及实验室特征
Characteristics of HIV Negative Adult Patients with Mycobacterium TuberculosisBlood Stream Infection
摘要
Abstract
Objective To summarize the clinical and laboratory characteristics of HIV-negative adult patients with Mycobacterium tuberculosis(MTB) blood stream infection (BSI).Methods We searched databases of the Clinical Laboratory and enrolled HIV-negative patients with blood culture positive for MTB,or the microbiologically confirmed pulmonary TB patients with blood culture negative for MTB from January 2010 to January 2016 in Peking Union Medical College Hospital,and analyzed the clinical and laboratory characteristics of these patients retrospectively.Results A total of 6999 patients with blood culture for Mycobacterium were screened,and 28 patients with MTB BSI (case group) and 32 patients with negative MTB blood culture but microbiologically confirmed pulmonary TB (control group) were enrolled in the present study.The proportion of female (57% vs.25%,P=0.011),the peak temperature [(39.70±0.78)℃ vs.(38.70±0.98)℃,P<0.001],the proportion of patients with more than one organ involved (71% vs.3%,P<0.001),the proportion of patients with severe complications (32% vs.3%,P=0.008) and the hypersensitive C reactive protein(hsCRP) level [94.74 (61.63-144.21)mg/L vs.59.97 (28.88-104.50)mg/L,P=0.016] in the case group were significantly higher than those in the control group.The lymphocyte count in the case group was significant lower than that in the control group [0.44(0.27-0.77)×109/L vs.1.03(0.52-1.42)×109/L,P=0.001].Conclusions HIV negative patients can also have MTB BSI.MTB BSI should be considered when female patients with higher temperature,multiple organs involvement,severe complications,lower lymphocytes and higher hsCRP level.关键词
结核分枝杆菌/血流感染/HIV阴性Key words
Mycobacterium tuberculosis/blood stream infection/HIV negative分类
医药卫生引用本文复制引用
张丽帆,边赛男,刘晓清,张月秋,杨启文,侍效春,徐英春..HIV阴性结核分枝杆菌血流感染成年患者临床及实验室特征[J].协和医学杂志,2017,8(2):161-166,6.基金项目
艾滋病和病毒性肝炎等传染病科技重大专项课题 (2014ZX10003003) （2014ZX10003003）
公益性行业科研专项课题(201402001) （201402001）
中国医学科学院医学与健康科技创新工程项目 (2016-I2M-1-013) （2016-I2M-1-013）
中国医学科学院北京协和医学院中央级公益性科研院所基本科研业务费课题(2016ZX310183-4) （2016ZX310183-4）
