新医学2017，Vol.48Issue(6)：425-427,3.DOI:10.3969/j.issn.0253-9802.2017.06.015
别嘌醇致药物超敏反应综合征一例
Allopurinol-induced DRESS syndrome: a case report
王淑香 1梁晶1
作者信息
- 1. 510800 广州,广州市花都区人民医院风湿科
- 折叠
摘要
Abstract
Allopurinol-induced drug reaction with eosinophilia and systemic symptoms(DRESS) syndrome is an acute and severe form of systemic drug-induced hypersensitivity syndrome.During the early onset of DRESS,it is initially manifested with delayed rash.It is likely to deteriorate due to misdiagnosis and insufficient treatment.In this article,we reported one case of allopurinol-induced DRESS with clinical manifestations including systemic multiple erythematosus rash,fever,multiple lymph node enlargement,eosinophilia,positive HLA-B*5801 and multi-organ dysfunctions.The condition of the patient deteriorated due to insufficient attention during the early onset,and was healed after active and effective therapy.The findings in this report suggest that early diagnosis and treatment are of significance for allopurinol-induced DRESS.Detection of HLA-B*5801 plays a pivotal role in the diagnosis of allopurinol-induced DRESS.关键词
别嘌醇/药物超敏反应综合征/诊断/治疗Key words
Allopurinol/Drug reaction with eosinophilia and systemic symptoms/Diagnosis/Treatment引用本文复制引用
王淑香,梁晶..别嘌醇致药物超敏反应综合征一例[J].新医学,2017,48(6):425-427,3.
