医疗卫生装备2017，Vol.38Issue(5)：14-17,28,5.DOI:10.7687/j.issn1003-8868.2017.05.014
一种用于战创伤急救护理的“液体绷带”研制
Development of liquid bandage used for emergency care of war wound
摘要
Abstract
Objective To develop a liquid bandage for self aid of war wound.Methods Solution A and B were prepared containing functional polymers derived from the biocompatible poly (ethylene glycol) and hyaluronic acid,which had ability of fast crosslinking reaction when they were mixed.Among them,A solution mainly comprised of mercapto group-containing hyaluronic acid derivative (HA-SH),water-solubility starch,propylene glycol,benzoic acid and etc.B solution contained pentaerythritol tetraacrylate derivative (4arm-PEG-Acrylate) and benzoic acid.The structure of mercapto group-containing hyaluronic acid derivative was confirmed by IR,1H-NMR and etc.HA-SH and 4arm-PEG-Acrylate were formulated to different concentrations (W/V) in different buffers.The two kinds of solution were mixed in different ratios,and in situ crosslinking hyaluronic acid hydrogel was obtained;the crosslinking time was recorded.The adhesive force and waterholding capacity of the hydrogel after crosslinking were measured by adding excipients such as water-solubility starch.Results In case the concentration of HA-SH and 4arm-PEG-Acrylate was 2％ and pH value was 11,the hydrogel film on wound skin would be quickly formed in 20 seconds for wound dressing after spraying A and B solution onto the wound skin.Conclusion The liquid bandage has strong adhesive force,high water-holding capacity and controllable crosslinking time,so it could be used as a novel wound dressing for war wound.关键词
液体绷带/水凝胶/快速交联/战创伤/急救/护理Key words
liquid bandage/hydrogel/fast crosslinking/war wound/first aid/nursing分类
医药卫生引用本文复制引用
薛迎春,王亚威,杨波,刘静,刘梅,鲁毅,段靖,邱彦..一种用于战创伤急救护理的“液体绷带”研制[J].医疗卫生装备,2017,38(5):14-17,28,5.基金项目
2014年度南京军区医学科技创新课题(14ZD25) （14ZD25）
