针刺研究2017，Vol.42Issue(3)：229-234,6.DOI:10.13702/j.1000-0607.2017.03.007
电针心经穴与非经非穴对rs-fMRI脑功能连接的影响
Effect of Electroacupuncture Stimulation of Acupoints of Heart Meridian on Brain Connectivity in 27 Healthy Volunteer Subjects
摘要
Abstract
Objective To observe the changes of brain rest-state functional connectivity following electroacupuncture (EA) stimulation of right Xia-Jiquan (HT 1),Shaohai (HT 3),Lingdao (HT 4) and Shenmen (HT 7) of the Heart Meridian and non-acupoints in healthy volunteers so as to provide an imaging basis for clinical treatment of some related disorders.Methods A total of 20 healthy volunteers who met the inclusion criteria were randomly divided into HT-acupoint group (n=10 cases) and non-acupoint group (n=10 cases) according to the visiting sequence.EA (2 Hz,2-5 mA) was applied to the right HT 1-HT 3,and HT 4-HT 7 (two outputs of the EA stimulator being connected to two acupuncture needle handles) and non-acupoints (4 spots on the imaginary mid-line between the HT and the Pericardium Meridian apart from the 4 acupoints HT 1-HT 3,and HT 4-HT 7) for 6 min.All the subjects underwent resting-state (rs) fMRI using an Achieva 1.5 T magnetic resonance image (MRI) scanner before and after EA stimulation.The bilateral posterior cingulate was used as the seed point and the functional connectivity data was analyzed by using DPARSF software and rs-fMRI data analysis toolkit.Results After EA stimulation of both acupoints and non-acupoints,a similar functional connectivity change was found in the bilateral postcentral gyrus,right inferior parietal lobule,and right inferior frontal gyrus.After EA of acupoints of the HT Meridian,an enhancement of brain functional connectivity was found in the left inferior temporal gyrus and right parahippocampal gyrus,and the newly activated brain regions were the left precentral gyrus,right precuneus,left angular gyrus,left inferior occipital gyrus and the left insula.After EA stimulation of non-acupoints,an increased functional connectivity was found in the left superior temporal gyrus,which was different from EA of acupoints of HT Meridian.Conclusion EA stimulation of acupoints of the HT Meridian can enhance the rs functional connectivity in some brain regions as the postcentral gyrus,inferior temporal gyrus,etc.which is related to mediating information of somatosensory,cognitive,affective,memory,cardiovascular activities,etc.in healthy volunteer subjects.The only difference between the two EA groups is an enhanced functional connectivity found in the left superior temporal gyrus after EA of non-acupoints.关键词
电针/脑功能连接/静息态功能磁共振成像/手少阴心经穴Key words
Electroacupuncture/Brain functional connectivity/Resting-state fMRI/Acupoints of Heart Meridian分类
医药卫生引用本文复制引用
石文英,章薇,李平,常小荣,娄必丹,李金香,黄洁,范磊,罗容,刘鼎..电针心经穴与非经非穴对rs-fMRI脑功能连接的影响[J].针刺研究,2017,42(3):229-234,6.基金项目
国家自然科学基金项目(No.81273861、81473754) （No.81273861、81473754）
湖南省教育厅科学研究项目(No.13C696) （No.13C696）
湖南省自然科学基金项目(No.11JJ5078) （No.11JJ5078）
湖南省科学技术厅科技计划一般项目(No.2013SK3091) （No.2013SK3091）
湖南省中医药科研计划项目(No.2016105) （No.2016105）
