局解手术学杂志2017，Vol.26Issue(6)：406-409,4.DOI:10.11659/jjssx.01E017018
轻微型肝性脑病患者脑缺省模式网络研究
Default-mode network in patients with minimal hepatic encephalopathy
摘要
Abstract
Objective To study the regional homogeneity (ReHo) of default-mode network (DMN) in patients with minimal hepatic encephalopathy (MHE) with resting state fMRI.Methods Eighteen MHE patients and eighteen healthy controls (HC) underwent standard resting state fMRI scan.The resting state fMRI data were analyzed with the ReHo method to observe the changes of DMN in the patients in contrast to the controls.Results Compared to healthy controls,MHE patients showed lower ReHo in bilateral MPFC/anterior cingulate cortex(V=13.257 cm3;MNI coordinates=3,24,66;t=-3.493 7),bilateral precuneus/posterior cingulate cortex(V=4.752 cm3;MNI coordinates=9,-54,45;t=-2.634 1),while higher ReHe in right medial prefrontal cortex(V=5.049 cm3;MNI coordinates=21,63,6;t=4.017 5).Conclusion In MHE patients,there is abnormal neuron activation in the widespread DMN regions under resting state, which indicated abnormal spontaneous activity consistency within DMN and endogenous brain function injury in MHE patients.ReHo can be used to observe DMN changes in MHE patients.关键词
轻微型肝性脑病/功能磁共振/静息态/脑缺省模式网络/局部一致性Key words
minimal hepatic encephalopathy/functional magnetic resonance imaging/resting state/default-mode network/regional homogeneity分类
医药卫生引用本文复制引用
陈永权,刘鲁,刘曦..轻微型肝性脑病患者脑缺省模式网络研究[J].局解手术学杂志,2017,26(6):406-409,4.基金项目
重庆市临床重点专科建设项目(渝卫医函[2015]517号) （渝卫医函[2015]517号）
