局解手术学杂志2017，Vol.26Issue(6)：419-422,4.DOI:10.11659/jjssx.12E016064
膝骨性关节炎患者慢性疼痛静息态脑功能局部一致性研究
Regional homogeneity of resting-state brain activity in knee osteoarthritis patients with chronic pain
摘要
Abstract
Objective To study the changes of resting-state brain activity in knee osteoarthritis(KOA)patients with chronic pain.Methods The data of 21 KOA patients (KOA group) and 21 healthy controls (HC group) who underwent standard resting-state fMRI scan were analyzed with regional homogeneity (ReHo) method to observe the changes in the patients in contrast to the controls.Results Compared to HC group,patients of the KOA group showed ReHo changes in bilateral frontal lobe,bilateral parietal lobe,bilateral temporal lobe,bilateral cerebellum,limbic system and default-mode network.Conclusion Patients with chronic pain demonstrate abnormal neuron activities in the brain regions, and control loops not only related with pain but also related with emotive function disorder and cognitive impairment.关键词
膝骨性关节炎/慢性疼痛/功能磁共振/静息态/局部一致性Key words
knee osteoarthritis/chronic pain/functional magnetic resonance/resting-state/regional homogeneity分类
医药卫生引用本文复制引用
石爱军,李春雷,吴媛,江开航,黄兴涛,罗甜,王静..膝骨性关节炎患者慢性疼痛静息态脑功能局部一致性研究[J].局解手术学杂志,2017,26(6):419-422,4.基金项目
2015重庆市临床重点专科建设项目(渝卫医函[2015]517号) （渝卫医函[2015]517号）
