中国临床药理学与治疗学2017，Vol.22Issue(5)：495-500,544,7.
叶酸靶向多西紫杉醇纳米肺吸入粉雾剂的制备及评价
Preparation and evaluation of inhaled dry powders based on folic acid-conjugated Docetaxel nanoparticles
摘要
Abstract
AIM:To prepare docetaxel-loaded folic acid-conjugated nanoparticles (NPs-DTX-FA) for the treatment of lung cancer.METHODS:The NPs-DTX-FA were prepared by the solvent evaporation method and the nanoparticles (NPs) were then co-spray dried with excipients to obtain inhaled dry powders.The physiochemical properties of NPs and inhaled dry powders were evaluated.MTT assay was employed to study the cytotoxicity and tumor-targeting property of the NPs.RESULTS:The diameter of LPs-DTX-FA was (100.1 ± 1.0) nm,the IC50 for NPs-DTX and NPs-DTX-FA were (2.09 ± 0.82) μmol/L and (0.80 ± 0.32) μmol/L,respectively.The fine particle fraction (FPF) and angle of repose (θ) of the inhaled dry powders were (21.10 ± 0.18)％ and (36.75 ± 0.52)°,respectively.CONCLUSION:The preparation of NPs-DTX-FA based inhaled dry powders was successful and this formulation represented a possibility of clinical application by achieving higher anti-cancer activity in tumor site and lower damage to healthy organs.关键词
多西紫杉醇/纳米粒/肺吸入粉雾剂Key words
docetaxel/nanoparticle/dry powder inhalation分类
医药卫生引用本文复制引用
朱晓婕,孔颖,刘琦,卢杨,赵娣,李宁,陈西敬..叶酸靶向多西紫杉醇纳米肺吸入粉雾剂的制备及评价[J].中国临床药理学与治疗学,2017,22(5):495-500,544,7.基金项目
国家自然科学基金项目(81473272 （）
81503148) （）
