中国临床药理学与治疗学2017，Vol.22Issue(5)：507-511,5.
芝麻素对阿尔茨海默病大鼠学习记忆及海马谷氨酸表达的影响
Effect of sesamin on learning-memory ability and expression of glutamate in hippocampus of rats with Alzheimer's disease
摘要
Abstract
AIM:To study the effect of sesamin on learning-memory ability and expression of glutamate (Glu) in hippocampus of rats with Alzheimer's disease.METHODS:Forty normal SD rats were selected,ten for blank control group (NS 5.0 mL · kg-1 · d-1).The rest were induced by intragastric administration of aluminium trichloride (AlCl3,15 mg · kg-1 · d-1) combined with intraperitoneal injection of D-galactose (D-gal,180 mg · kg-1 · d-1) for 20 weeks.After twelve weeks,rats were subsequently randomized into AD model group (NS 5.0 mL · kg-1 · d-1),sesamin low dose group (80 mg · kg-1 · d-1),sesamin high dose group (160 mg · kg-1 · d-1) (n =10).After eight consecutive weeks of drug administration,Morris water maze was used to test the learning-memory ability of rats.Immunohistochemical staining was used to determine the expression of Glu protein in hippocampal neurons.Western blot method was used to detect the expression of Glu in hippocampus.RESULTS:Sesamin can reduce the escape latency of AD rat,while increase the platform crossing numbers,improve their learning-memory ability,and reduce the positive cells and protein expression of Glu at the same time.CONCLUSION:Sesamin can reduce the expression of Glu by antagonizing Glu receptor and decrease neural excitatory toxicity,thus improving the learning-memory ability of alzheimerg disease rats.关键词
芝麻素/阿尔茨海默病/学习记忆/谷氨酸Key words
sesamin/Alzheimer's disease/learning-memory/glutamate分类
医药卫生引用本文复制引用
王欢,杨解人,张俊秀,姚海,马同军..芝麻素对阿尔茨海默病大鼠学习记忆及海马谷氨酸表达的影响[J].中国临床药理学与治疗学,2017,22(5):507-511,5.基金项目
皖南医学院中青年科研基金(WK201606) （WK201606）
