中国临床药理学与治疗学2017，Vol.22Issue(5)：531-537,7.
基于Wnt/β-链蛋白表达评价丹蛭降糖胶囊对2型糖尿病患者血管的保护作用
Danzhijiangtang capsule protects vasculopathy of T2DM: an evaluation based on the expression of Wnt/β-catenin
摘要
Abstract
AIM:To evaluate the protective effect of Danzhijiangtang capsule on vasculopathy of type 2 diabetes mellitus (T2DM) patients by observing the expression of Wnt/β-catenin,GSK-3β,and the change of carotid intima media thickness (IMT) and plaque area.METHODS:One hundred and two T2DM patients were randomly allocated into the control group and the treatment group (n =51).Both groups received conventional therapy (hypoglycemic drugs orally),while the treatment group was given extra Danzhijiangtang capsule.Therapy was conducted for 16 weeks.RESULTS:The total effective rate of the treatment group was significantly better than that of the control group (84.31％ vs.64.71％,P ＜ 0.05).Traditional Chinese Medicine (TCM) symptom scores,FPG,2 hPG,HbA1c,TC,TG,LDL,HDL,carotid intima media thickness and plaque area were improved in both groups.Compared with the control group,TCM scores,2 hPG,HbA1,TG and LDL decreased significandy (P ＜ 0.05 or P ＜ 0.01) in the treatment group,which also presented better improvement of IMT (P ＜ 0.05) though the comparison of plague area exhibited no significant difference (P ＞ 0.05);The expressions of Wnt/β-catenin and GSK-3β also decreased significantly in the treatment group (P ＜ 0.05).CONCLUSION:Danzhijiangtang capsule can alleviate the clinical symptoms of T2DM,and can improve or even reverse carotid atherosclerosis to a certain extent.关键词
2型糖尿病/血管病变/丹蛭降糖胶囊/Wnt/β-链蛋白/糖原合成酶激酶-3Key words
type 2 diabetes mellitus/vasculopathy/Danzhijiangtang capsule/Wnt/β chain protein/glycogen synthase kinase-3分类
医药卫生引用本文复制引用
倪英群,谢峰涛,方朝晖..基于Wnt/β-链蛋白表达评价丹蛭降糖胶囊对2型糖尿病患者血管的保护作用[J].中国临床药理学与治疗学,2017,22(5):531-537,7.基金项目
国家科技部国家科技支撑计划(2012BA126B00) （2012BA126B00）
国家中医药管理局国家基本公共卫生服务项目(20131012) （20131012）
安徽省高校自然科学研究项目(KJ2015A136) （KJ2015A136）
国家自然科学基金立项项目(81573944) （81573944）
安徽省卫生计生委中医药科研课题(2016zy73) （2016zy73）
