中国临床药理学与治疗学2017，Vol.22Issue(5)：538-544,7.
一氧化氮合酶基因多态性与常用降压药疗效的关联研究
Association study of NOS3 genetic polymorphism and the efficacy of anti-hypertensive drug treatment on patient with essential hypertension
摘要
Abstract
AIM:To evaluate the effect of NOS3 gene polymorphism on anti-hypertensive drug treatment for patient with essential hypertension (EH).METHODS:General information and Clinical biochemical indicators of EH patients taking compound reserpine,hypertension pill and Zhenju hypertension pill were collected.RELP-PCR was used to test the polymorphism of NOS3 gene (rs4496877,rs1808593 and rs3918186).A quantitative trait analysis was performed to evaluate the relation between NOS3 genetic variation and blood pressure taking different anti-hypertensive drugs.RESULTS:Quantitative trait analysis showed significant differences in diastolic blood pressure (DBP) among the genotypes (TT,TG and GG) of rs1808593 in patients taking the hypertension pill after adjusting covariants (P =0.035).Stratification analysis indicated that DBP of male patients taking the hypertension pill significantly decreased with the variation (T ＞ G) of rs1808593 (P =0.046).For patients (age ≥ 55) taking the hypertension pill,DBP of genotype TT was significantly higher than genotypes TG and GG of rs1808593 (P =0.008).CONCLUSION:NOS3 gene rs1808593 mutation might relate to the anti-hypertensive effect of the hypertension pill.关键词
NOS3基因/基因多态性/原发性高血压/药物疗效Key words
NOS3 gene/gene polymorphisms/essential hypertension/drug efficacy分类
医药卫生引用本文复制引用
金岳龙,姚应水,王林红,朱丽君,梁伟,段滢,杨松,陈燕春,赵祥海,沈冲..一氧化氮合酶基因多态性与常用降压药疗效的关联研究[J].中国临床药理学与治疗学,2017,22(5):538-544,7.基金项目
国家自然科学基金项目(81072367,81541071,81673266) （81072367,81541071,81673266）
安徽高校省级自然科学研究项目(KJ2014A265) （KJ2014A265）
安徽省高校优秀青年人才支持计划(2014年安徽省教育厅) （2014年安徽省教育厅）
