中国临床药理学与治疗学2017，Vol.22Issue(5)：556-559,4.
探讨万古霉素硫酸钙联合超短波治疗创伤性骨髓炎临床疗效及安全性
Efficacy and safety of vancomycin calcium sulfate combined with ultrashort wave in the treatment of traumatic osteomyelitis
摘要
Abstract
AIM:To evaluate the efficacy and safety of vancomycin calcium sulfate combined with ultrashort wave in the treatment of traumatic osteomyelitis.METHODS:Severty-four cases of traumatic osteomyelitis were randomly divided into control group and treatment group (37 cases each).The control group was given hydrochloric acid (0.8 g/ d) for 3 days (2 times a day) before surgery.Selection of calcium sulfate bone graft substitute (5-10 g) and hydrochloric acid (1 g) were added to make paste.Hydrochloric acid (0.8 g/d) was given after the operation.The treatment group received ultrashort wave therapy after operation and all patients were treated for 28 days.The clinical effects,hemorheology index,the serum C-reactive protein (CRP),serum tumor necrosis factor (TNF-α),nuclear factor kappa B (NF-κB),and adverse reactions were compared between the two groups.RESULTS:After treatment,the total effective rate in the control group was (78.38％),which was significantly lower than that in the experimental group (97.30％) (P ＜ 0.05).After treatment,the erythrocyte aggregation index of the experimental group was higher than that of the control group (P ＜ 0.05).Plasma viscosity,whole blood viscosity and ESR level were lower than the control group (P ＜ 0.05).Levels of serum CRP,TNF-o and NF-κB in the experimental group were significantly lower than those in the control group (P ＜ 0.05).Levels of serum CRP,TNF-α and NF-κB were significantly lower than control group (P ＜ 0.05).The adverse reaction rate of control group was 13.51％,the treatment group was 8.11％,and the difference was not statistically significant (P ＞ 0.05).CONCLUSION:Vancomycin calcium sulfate combined with ultrashort wave in the treatment of traumatic osteomyelitis is effective and safe.关键词
万古霉素/硫酸钙/超短波/创伤性骨髓炎/临床疗效/安全性Key words
vancomycin/calcium sulfate/ultrashort wave/traumatic osteomyelitis/clinical efficacy/safety分类
医药卫生引用本文复制引用
俞华军,黄凯,张展,郭峭峰,张晓文,张春..探讨万古霉素硫酸钙联合超短波治疗创伤性骨髓炎临床疗效及安全性[J].中国临床药理学与治疗学,2017,22(5):556-559,4.基金项目
浙江省医药卫生科技计划(2012RCA011) （2012RCA011）
