中国临床药理学与治疗学2017，Vol.22Issue(5)：560-564,5.
硫酸氨基葡萄糖联合参麦注射液治疗膝骨性关节炎的疗效研究
Effect of glucosamine sulfate combined with Shenmai injection on knee osteoarthritis
摘要
Abstract
AIM:To investigate the effect of glucosamine sulfate combined with Shenmai injection on knee osteoarthritis.METHODS:One hundred and twenty patients with knee osteoarthritis were randomly divided into combined group and control group,60 cases in each.The control group was treated with glucosamine sulfate only,while the combined group was given glucosamine sulfate (0.5 g per time,3 times per day) plus Shenmai injection (5 mL per knee,1 time per week).Both groups were treated for 6 weeks,and the clinical efficacy of the two groups was observed.RESULTS:The total effective rate of combined group (91.67％) was significantly higher than that of the control (78.33％) (P ＜ 0.05).After treatment,the improvement of The Western Ontario and McMaster Universities Arthritis Index (WOMAC) in the combined group was significantly higher than that in the control group (P ＜ 0.05).No significant difference was observed with respect to the incidence of adverse reactions between the two groups (P ＞ 0.05).Levels of serum IL-17 and IL-18 in both groups were significantly decreased,yet the combined group exhibited more significant decrease than the control group (P ＜ 0.05).Levels of TGF-β,IGF-1 and FGF-2 were significantly increased,yet the combined group exhibited more significant increase than the control group (P ＜ 0.05).CONCLUSION:Glucosamine sulfate combined with Shenmai injection demonstrate better effect on knee osteoarthritis with low incidence of adverse reactions.Its mechanism may be related to the decrease of serum levels of IL-17,IL-18 levels and the increase of TGF-β,IGF-1 and FGF-2 concentrations.关键词
膝骨性关节炎/硫酸氨基葡萄糖/参麦注射液/临床疗效/血清相关细胞因子Key words
knee osteoarthritis/glucosamine sulfate/Shenmai injection/clinical effect/serum related cytokines分类
医药卫生引用本文复制引用
茆红霞,金灵青,刘双春..硫酸氨基葡萄糖联合参麦注射液治疗膝骨性关节炎的疗效研究[J].中国临床药理学与治疗学,2017,22(5):560-564,5.基金项目
浙江省中医药科学研究基金项目(2013ZA122) （2013ZA122）
