中国临床药理学与治疗学2017，Vol.22Issue(5)：570-573,588,5.
血清B型利钠肽前体和血压变异性在非心源性急性脑梗死患者临床应用中的价值
Application of serum B type natriuretic peptide precursor and blood pressure variability in patients with non-cardiogenic ischemic stroke
摘要
Abstract
AIM:To discuss the application of serum B type natriuretic peptide precursor and blood pressure variability in patients with non-cardiogenic ischemic stroke.METHODS:Eighty-six patients with non cardiogenic acute cerebral infarction were selected as the case group,and 40 healthy volunteers were selected as control group.The serum levels of pro-BNP and blood pressure variability were compared between the two groups.RESULTS:The level of serum pro-BNP in the case group was (984.63 ± 148.67) ng/L,which was significantly higher than that of the control group (138.44 ± 30.75) ng/L (P ＜ 0.01).The 24 h systolic pressure variation coefficient(24 h SBPCV),24 h diastolic pressure variation coefficient (24 h DBPCV),24 h systolic pressure standard deviation (24 h SBPSD),24 h diastolic pressure standard deviation (24 h DBPSD) and comparison of blood pressure variability coefficients independent of mean (VIM) between the two groups were statistically significant (P ＜ 0.01).Serum pro-BNP was positively correlated with 24 h SBPCV,24 h DBPCV,24 h SBPSD,24 h DBPSD.The serum pro-BNP level in the death group was (1 326.36 ± 156.85) ng/L,which was significantly higher than that of the survival group (910.28 ± l18.47) ng/L (P＜0.01).The difference of 24 h SBPCV,24 h DBPCV,24 h SBPSD,24 h DBPSD,VIM between the two groups was statistically significant (P ＜ 0.05).CONCLUSION:The level of serum pro-BNP and the variation of blood pressure are closely related to the prognosis of patients with non-cardiogenic acute cerebral infarction.关键词
非心源性急性脑梗死/血清B型利钠肽前体/血压变异性/预后Key words
non-cardiogenic ischemic stroke/serum B type natriuretic peptide/blood pressure variability/prognosis分类
医药卫生引用本文复制引用
陈涛,严永兴,沈咏慧..血清B型利钠肽前体和血压变异性在非心源性急性脑梗死患者临床应用中的价值[J].中国临床药理学与治疗学,2017,22(5):570-573,588,5.基金项目
浙江省医药卫生项目(2012KYB224) （2012KYB224）
