中国临床药理学与治疗学2017，Vol.22Issue(5)：574-579,6.
血塞通软胶囊对急性腔隙性梗死合并脑微出血患者临床疗效的评价
Effect of Xuesaitong soft capsule on acute lacunar cerebral infarction combined with cerebral microbleeds
摘要
Abstract
AIM:To evaluate the clinical efficacy of Xuesaitong soft capsule in the treatment of acute lacunar cerebral infarction combined with cerebral microbleeds and its influence on S100B and soluble receptor for advanced glycation end products (sRAGE) in serum.METHODS:Eighty-six patients with acute lacunar cerebral infarction and cerebral microbleeds were randomly divided into control group and treatment group,43 cases in each group.Control group received basic treatment.Treatment group were treated with Xuesaitong soft capsule additionally for a course of 8 weeks.Clinical efficacy,scores of CSS,NIHSS and MRS,levels of S100B and sRAGE in serum and adverse reactions were compared between the two groups.RESULTS:The effective rate in treatment group was 90.70％,significantly higher than 74.42％ in control group (P ＜0.05).After treatment,scores of CSS and NIHSS in treatment group were significantly lower than those in control group (P ＜ 0.01).The level of S100B in serum in treatment group was significantly lower than that in control group (P ＜ 0.05),and the level of sRAGE in serum in treatment group was significantly higher than that in control group (P ＜ 0.05).During treatment,no significant adverse reactions were exhibited.CONCLUSION:Xuesaitong soft capsule has obvious curative effect on acute lacunar cerebral infarction combined with cerebral microbleeds,which is referential for clinical application.关键词
脑微出血/血塞通软胶囊/腔隙性脑梗死/钙黏蛋白S100B/可溶性糖基化终产物受体Key words
cerebral microbleeds/xuesaitong soft capsule/acute lacunar cerebral infarction/S100B/soluble receptor for advanced glycation end products分类
医药卫生引用本文复制引用
王美华,翁秋燕,查芹,牛艳芳..血塞通软胶囊对急性腔隙性梗死合并脑微出血患者临床疗效的评价[J].中国临床药理学与治疗学,2017,22(5):574-579,6.基金项目
宁波市科技惠民项目(2015C50007) （2015C50007）
浙江省医药卫生科技项目计划(2015KYB341) （2015KYB341）
