中国临床药理学与治疗学2017，Vol.22Issue(5)：580-583,4.
右美托咪定在老年患者内镜黏膜下剥离术中的应用
Application of dexmedetomidine in elderly patients during ESD operation
摘要
Abstract
AIM:To investigate the effects of dexmedetomidine in elderly patients with endoscopic submucosal dissection (endoscopic submucosal dissection,ESD) used in operation.METHODS:Sixty elderly patients who underwent ESD operation in our hospital were divided into study group and control group,each group included 30 cases.The study group was given 0.5 μg/kg infusion of dexmedetomidine.The control group was given the same amount of saline.During operation,two groups weregiven continuous infusion of propofol.The operation time,anesthesia time,recovery time,propofol dosage were compared between the two groups.Post-operative cognitive function (POCD) was assessed by mini mental state examination (MMSE) before and 6 hours after operation,on the postoperative day 1 and day 3 after operation,and the incidence of POCD was assessed.RESULTS:Comparison of operation time,anesthesia time in two groups.The difference was not statistically significant (P ＞ 0.05).The recovery time and propofol dosage in the study group were significantly lower than those in the control group.The difference was statistically significant (P ＜ 0.05).Postoperative 6 hours,postoperative day 1,postoperative day 3,the observation group MMSE score was significantly higher than that of the control group.The difference was statistically significant (P ＜ 0.05).Postoperative 6 hours,postoperative day 1,postoperative day 3,the study group POCD was significantly lighter than that of the control group.The difference was statistically significant (P ＜ 0.05).The incidence of adverse reactions in the study group (6.67％) was significantly lower than that in the control group (30％).The difference was statistically significant (P ＜ 0.05).CONCLUSION:Dexmedetomidine has a protective effect on cognitive function in elderly patients after ESD surgery.关键词
右美托咪定/内镜黏膜下剥离术/老年/认知功能/术后认知功能障碍Key words
dexmedetomidine/ESD/elderly/cognitive function/POCD分类
医药卫生引用本文复制引用
邓迎丰..右美托咪定在老年患者内镜黏膜下剥离术中的应用[J].中国临床药理学与治疗学,2017,22(5):580-583,4.基金项目
宁波市科技局科技计划项目(2012C50023) （2012C50023）
