中国临床药理学杂志2017，Vol.33Issue(9)：771-773,777,4.DOI:10.13699/j.cnki.1001-6821.2017.09.001
万古霉素血清谷浓度监测及临床应用分析
Analysis of serum trough concentration monitoring and clinical use of vancomycin in patients
王翠红 1栾婷 2叶蕊 1吴小街 1赵立1
作者信息
- 1. 中国医科大学附属盛京医院呼吸科,沈阳110004
- 2. 中国医科大学附属盛京医院重症医学科,沈阳110004
- 折叠
摘要
Abstract
Objective To investigate the clinical application of vancomycin and thestatus quo of vancomycin serum trough concentration in our hospital intensive care unit (ICU) patients.Methods Fluorescence polarization immunoassay was used for vancomycin serum trough concentration test.The clinical information (primary diseases,bacteriological culture,vacomycin serum trough concentration,clinical efficacy,renal function) of 204 adult ICU inpatients who had been treated with vancomycin and their serum concentration were analyzed retrospectively.Results The bacteria detection rate was 25.6％.The drug indications bacteriology coincidence rate was 41.6％.The clinical cure rate was 70.6％.And 275 serum vancomycin trough concentration data were collected from 204 ICU inpatients.The values of vancomycin serum trough concentration were 1.11-50 μg · mL-1,with an average of (13.32 ± 8.40)μg· mL-1.The rate was 14.5％ of target concentration 15-20μg · mL-1.Forty-two patients (20.6％) experienced nephrotoxicity,and four patients (2.0％) could not be judged due to insufficient data.Conclusion The value of vancomycin serum trough concentration of the 204 cases were less in effective range which should be paid attention to the serum concentration monitoring of ICU inpatients to achieve an ideal individual administration according to clinical practice.关键词
万古霉素/血清谷浓度/肾毒性Key words
vancomycin/serum trough concentration/nephrotoxicity分类
医药卫生引用本文复制引用
王翠红,栾婷,叶蕊,吴小街,赵立..万古霉素血清谷浓度监测及临床应用分析[J].中国临床药理学杂志,2017,33(9):771-773,777,4.
