中国临床药理学杂志2017，Vol.33Issue(9)：774-777,4.DOI:10.13699/j.cnki.1001-6821.2017.09.002
醒脑静注射液联合阿托伐他汀钙胶囊治疗急性脑出血的临床研究
Clinical trial of Xingnaojing injection combined with atorvastatin calcium in the treatment of acute cerebral hemorrhage
摘要
Abstract
Objective To evaluate the clinical efficacy and safety of Xingnaojing injection combined with atorvastatin calcium in the treatment of acute cerebral hemorrhage.Methods A total of 68 cases with acute cerebral hemorrhag were divided into control group and treatment group,each group 34 cases.Patients in both groups were given regular treatment.Patients in control group were orally given atorvastatin calcium capsules 20 mg,once a day.Patients in treatment group were received Xingnaojing injection 20 mL by intravenous drip,twice a day on the basis of control group.All patients were treated for 21 d.The clinical efficacy,C reactive protein (CRP),interleukin-1β (IL-1 β),tumor necrosis factor-α (TNF-o),nitric oxide (NO),malondialdehyde (MDA),superoxide dismutase (SOD) and adverse drug reactions were compared in two groups.Results The clinical efficacy in treatment group was 94.12％ (32/34),had significant difference with that in control group,which was 76.47％ (26/34,P ＜0.05).After treatment,the serum CRP of treatment group and control group were (3.72 ±0.86),(5.18 ±0.51)mg· L-1,IL-1β were (4.02 ±0.41),(5.48 ±0.58)ng· L-1,TNF-αwere (19.47 ±2.13),(29.59 ±3.04) μg· L-1,NO were (3.03 ±0.34),(4.11 ±0.42) ng· L-1,MDAwere (6.04 ±0.61),(7.17 ±0.76) μmol · mL-1,SOD were (162.01 ± 16.34),(142.63 ±14.64)U · mL-1 (P ＜ 0.05).In treatment group,patients had headache,nausea,rash,incidence of adverse drug reactions was 8.82％ (3/34 cases).In control group,patients had headache,vision fuzzy,nausea,insomnia,incidence of adverse drug reactions was 14.70％ (5/34 cases,P ＞ 0.05).Conclusion Xingnaojing injection combined with atorvastatin calcium in the treatment of acute cerebral hemorrhag was effective with high safety.关键词
醒脑静注射液/阿托伐他汀钙胶囊/急性脑出血/白细胞介素-1β/超氧化物歧化酶Key words
Xingnaojing injection/atorvastatin calcium/acute cerebral hemorrhage/interleukin-1 β/superoxide dismutase分类
医药卫生引用本文复制引用
何玉清,魏立平,李文波,张耀慧,庞红立,严澎..醒脑静注射液联合阿托伐他汀钙胶囊治疗急性脑出血的临床研究[J].中国临床药理学杂志,2017,33(9):774-777,4.基金项目
河南省科技厅科技攻关基金资助项目(112102310173) （112102310173）
