中国临床药理学杂志2017，Vol.33Issue(9)：782-785,4.DOI:10.13699/j.cnki.1001-6821.2017.09.004
盐酸纳布啡注射液用于剖宫产术后镇痛的临床研究及其对产后抑郁的预防作用
Clinical trial of nalbuphine hydrochloride injection on analgesia after cesarean section and its preventive effect on postpartum depression
摘要
Abstract
Objective To observe the clinical efficacy and safety of nalbuphine hydrochloride injection on cesarean section analgesia and its preventive effect on postpartum depression.Methods A total of 400 term pregnancy maternal with cesarean section were randomly divided into groups A,B,C,D with 100 cases per group.Group A was treated with sufentanil 100 μg.Groups B,C,D were treated with hydrochloric nalbuphine 1.5,2.0 and 2.5 mg · kg-1,respectively.Four groups received patient-controlled intravenous analgesia.The visual analogue scale (VAS) and Ramsay sedation scores (RSS) of 6,12,24 h after operation,depression status and adverse drug reactions were compared between four groups.Results 6,12,24 h after operation,in group A,VAS were (3.21 ± 0.44),(3.15 ± 0.49),(2.06 ± 0.49) points,RSS were (2.08 ± 0.37),(2.05 ± 0.35),(1.85 ± 0.23) points;in group B,VASwere (2.17±0.35),(2.00±0.38),(1.45 ± 0.38) points,RSS were (2.01 ±0.19),(1.91±0.21),(1.72 ± 0.18) points;in group C,VAS were (2.08 ± 0.22),(1.53 ± 0.26),(0.75 ± 0.13)points,RSS were (1.71±0.15),(1.75±0.12),(1.46±0.15)points;in group D,VAS were (2.10±0.21),(1.52 ±0.21),(0.72 ± 0.11) points,RSS were (1.64 ± 0.22),(1.62 ± 0.15),(1.43 ± 0.21) points,there were significant differences in VAS score and RSS score at different times between groups C,D and groups A,B (P ＜ 0.05).3 d postpartum,the depression rates in groups A,B,C,D were 35.00％ (35/100 cases),27.00％ (27/100 cases),12.00％ (12/100 cases),26.00％ (26/100 cases),with significant differences between group C and groups A,B,D (P ＜ 0.05).The adverse drug reactions in group A were heart rate,vomiting,diarrhea and rash,which in group B and C were rapid heartbeat,nausea,vomiting and urinary retention,in group D were rapid heartbeat,nausea,vomiting,diarrhea and rash.The incidences of adverse drug reactions were 14.00％,10.00％,11.00％,21.00％,with significant differences between group D and groups A,B,C (P ＜ 0.05).Conclusion Nalbuphine 2.0 mg · kg-1 has a definitive clinical efficacy on analgesic and sedative after cesarean section,with low postpartum depression rate and adverse reactions rate.关键词
盐酸纳布啡注射液/剖宫产/术后镇痛/抑郁Key words
hydrochloric nalbuphinea injection/cesarean section/postoperative analgesia分类
医药卫生引用本文复制引用
王敦亮,王秘群,申荣,史建稳,张鹏..盐酸纳布啡注射液用于剖宫产术后镇痛的临床研究及其对产后抑郁的预防作用[J].中国临床药理学杂志,2017,33(9):782-785,4.基金项目
青岛市医药科研指导计划基金资助(2015-WJZD085) （2015-WJZD085）
