中国临床药理学杂志2017，Vol.33Issue(10)：873-876,4.DOI:10.13699/j.cnki.1001-6821.2017.10.003
益气化痰汤辅助治疗老年晚期肺癌的临床研究
Clinical trial of Yiqi Huatan decoction in the treatment of elderly advanced lung cancer
摘要
Abstract
Objective To observe the clinical efficacy and safety of Yiqi Huatan decoction in the treatment of elderly advanced lung cancer.Methods Eighty-one elderly patients with advanced lung cancer were randomly divided into control group (n =40 cases) and treatment group (n =41 cases).Control group was given 75 g · m-2 paclitaxel intravenous infusion on day 1 + 60 mg · m-2 cisplatin intravenous infusion on day 1 + gefitinib 250 mg oral qd.Treatment group was treated with Yiqi Huatan decoction once daily,on the basis of control group.Two groups were treated for 4 cycles with 7 d per cycle.The clinical efficacy,serum levels of cancer embryonic antigen (CEA),cytokeratin fragment 19 (CYFRA21-1),neuron specific enolase (NSE),vascular endothelial growth factor (VEGF),extracellular signal regulated kinase (ERK) and the incidence of adverse drug reactions were compared between two groups.Results After treatment,the disease control rates in treatment and control groups were 90.24％ (37/41 cases) and 72.50％ (29/40 cases),with significant difference(P ＜0.05).After treatment,the levels of CEA in treatment and control groups were (92.74 ± 10.57),(120.45 ± 13.96) ng · mL-1;CYFRA21-1 were (92.74 ± 10.57),(114.54±11.74)ng· mL-1;NSE were (7.04 ±0.81),(8.45 ±0.94)ng · mL-1;ERK were (0.97 ±0.11),(1.49±0.16)μg · mL-1;VEGF were (5.80 ± 0.63),(17.74 ± 1.92) ng· mL-1,with significant differences (P ＜0.05).The survival rates of 0.5,1 and 2 years in treatment group were 97.56％,95.12％,90.24％;the survival rates of 0.5,1 and 2 years in the control group were 92.50％,87.50％,72.50％,with significant difference (P ＜0.05).Adverse drug reactions were focused on chest pain,loss of appetite and vomiting,and fever in two groups,and the incidence of adverse drug reactions in treatment and control groups were 7.32％ and 17.50％,with significant difference (P ＜ 0.05).Conclusion Yiqi Huatan decoction has a definitive clinical efficacy and safety in the treatment of elderly advanced lung cancer.关键词
紫杉醇注射液/顺铂注射液/吉非替尼片/益气化痰汤/老年晚期肺癌Key words
paclitaxel injection/cisplatin injection/gefitinib/Yiqi Huatan decoction/elderly advanced lung cancer分类
医药卫生引用本文复制引用
李长生..益气化痰汤辅助治疗老年晚期肺癌的临床研究[J].中国临床药理学杂志,2017,33(10):873-876,4.基金项目
河南省医学科技攻关计划基金资助项目(B112102310102) （B112102310102）
