中国临床药理学杂志2017，Vol.33Issue(10)：877-879,883,4.DOI:10.13699/j.cnki.1001-6821.2017.10.004
溴芬酸钠滴眼液治疗白内障术后炎症的临床研究
Clinical trial of bromfenac sodium eye drop in the treatment of postoperative inflammation of cataract
摘要
Abstract
Objective To evaluate clinical efficacy and safety of domestic and imported bromfenac sodium eye drops in the treatment of posto-perative inflammation of cataract.Methods A total of 134 cataract patients were divided into treatment group (n =66) and control group (n =68).Control group was treated with imported bromfenac sodium eye drops,and treatment group was given domestic bromfenac sodium eye drops,1 drop in morning and evening respectively.All patients were treated for 14 d.The clinical efficacy and adverse drug reactions in two groups were compared.Results After treatment,the cured rate and effective rate in treatment group were 53.97％ (34/63 cases),46.03％ (29/63 cases).The cured rate and effective rate in control group were 67.74％ (42/62 cases),32.26％ (20/62 cases).There was no significant difference between two groups (P ＞ 0.05).There were no statistical differences between the two groups in ocular tolerance,burning sensation,ophthalmic itching and corneal epithelium spotting at 3,7,14 d after treatment (P ＞ 0.05).There were 1 case of eye discomfort,2 cases of liver function abnormal and 2 cases of urine leukocyteabnormalin control group,with the incidence rate of 7.35％ (5/68 cases).There were 1 case of infection in urinary system,1 case of dizziness,1 case of pathogenesis of primary acute angle-closure glaucoma in right eye,1 case of floating cells in anterior chamber,with the incidence rate of 6.06％ (4/66 cases,P ＞0.05).Conclusion The clinical efficacy of domestic bromfenac sodium eye drops in the treatment of cataract patients is comparable to imported bromfenac sodium eye drops.The clinical efficacy is exactly,with lower adverse drug reactions and price.关键词
溴芬酸钠滴眼液/白内障手术/炎症Key words
bromfenac sodium eye drops/cataract surgery/inflammation分类
医药卫生引用本文复制引用
包志淑,李瑾,郁引飞,沈汞民,金艳,赵云娥..溴芬酸钠滴眼液治疗白内障术后炎症的临床研究[J].中国临床药理学杂志,2017,33(10):877-879,883,4.基金项目
国家重大新药创制专项基金资助项目(2014ZX09303301) （2014ZX09303301）
