中国临床药理学杂志2017，Vol.33Issue(10)：888-892,5.DOI:10.13699/j.cnki.1001-6821.2017.10.007
糖皮质激素治疗嗜酸细胞肉芽肿性多血管炎的近期与远期疗效分析
Analysis the short and long-term effectiveness of glucocorticoid in the treatment of eosinophilic granulomatosis with polyangiitis
高懿卓 1郭晓雪 1范晶晶 1叶蕊 1赵立1
作者信息
- 1. 中国医科大学附属盛京医院第一呼吸内科,沈阳110004
- 折叠
摘要
Abstract
Objective To investigate the short-term and long-term clinical effect of eosinophilic granulomatosis with polyangiitis (EGPA) patients treated with corticosteroids and/or immunosuppressants.Methods A total of 36 cases who fulfilled the eosinophilic granulomatosis with polyangiitis diagnosis from January 2008 to February 2016 were collected including their information and the acute clinical symptoms as well as laboratory findings before and after treatment to evaluate short-term effect.We also evaluated the long-term effect by outpatient or telephone at September 2016.All patients were treated with drugs,including but not limited to corticosteroids,others consisting of immunosuppressants such as cyclophosphamide,azathioprine;glucocorticoid dosage based on the severity and effects,corticosteroids including intravenous and oral form,immunosuppressants for intravenous form.Results We assessed short-term effectiveness by 32 patients with initial pure glucocorticoid treatment,clinical symptoms were improved.The eosinophils before and after treatment were (1.48 ± 0.81) × 109/L,(0.22 ± 0.36) × 109/L;percentage of eosinophils were (17.35 ± 8.50)％,(2.95 ± 4.90)％;total immunoglobulin E were (750.95 ± 1040.11),(343.87 ± 489.53) U · mL-1;C reactive protein were (44.44 ± 37.65),(17.80 ± 13.29)mg · L-1;erythrocyte sedimentation rates were (58.25 ± 40.61),(23.55-± 10.34) mm · h-1 Five-factors score (FFS) showed that higher scores meant more recurrence,which meant bad long-term effectiveness.Conclusion Important organ involvement indicated poor efficacy of long-term glucocorticoid treatment,which required immunosuppressants therapy as early as possible in order to reduce the recurrence.关键词
嗜酸细胞肉芽肿性多血管炎/糖皮质激素/受累器官Key words
eosinophilic granulomatosis with polyangiitis/glucocorticoid/involved organs分类
医药卫生引用本文复制引用
高懿卓,郭晓雪,范晶晶,叶蕊,赵立..糖皮质激素治疗嗜酸细胞肉芽肿性多血管炎的近期与远期疗效分析[J].中国临床药理学杂志,2017,33(10):888-892,5.
