摘要
Abstract
Objective To compare the effects of weight loss by dieting and aerobic exercise on the improvement of nonalcoholic fatty liver disease.Methods Obese individuals〔n=30,BMI ranged from 26 to 35 kg/m2,with an average of (31.8±1.6) kg/m2〕 with clinically confirmed nonalcoholic fatty liver disease (NAFLD) admitted in Department of Gastroenterology,the Affiliated Puai Hospital of Tongji Medical College,Huazhong University of Science and Technology from May 2013 to May 2015 were recruited.They were divided into weight loss group (group A,n=15) and aerobic exercise group (group B,n=15) by the random number table.The daily calorie intake for individuals in group A was about 1 500 kcal,and they did not do any aerobic exercise.The individuals in group B did supervised 150-min aerobic exercise with the heart rate value as 45%~55% of HRmax,3 times a week,for 4 weeks without changing the eating habits and increasing the nutrient intake.Comparisons were made between the groups in terms of the ALT,fasting plasma glucose(FPG),free fatty acid (FFA),fasting insulin(INS),and homeostasis model assessment of insulin resistance (HOMA-IR) and visceral adipose tissue (VAT) area before and after the intervention.Results The distribution of gender and age was similar in both groups(P>0.05).Before and after the intervention,the weight and BMI did not differ significantly between the groups (P>0.05).Before intervention,two groups had no significant differences in the ALT,FPG,FFA,INS and HOMA-IR (P>0.05);after intervention,ALT,FPG,INS and HOMA-IR of two groups were still similar,but the FFA in group B was substantially lower than that in group A(P<0.05).No notable differences in the VAT area were found between the groups before intervention(P>0.05);however,after intervention,group B had much smaller VAT area than group A(P<0.05).Conclusion Compared with weight loss by dieting,aerobic exercise is more effective for NAFLD.关键词
脂肪肝/节食减重/有氧运动Key words
Fatty liver/Weight loss by dieting/Aerobic exercise分类
医药卫生
