中国全科医学2017，Vol.20Issue(16)：1955-1960,6.DOI:10.3969/j.issn.1007-9572.2017.16.011
中老年人血清维生素D水平与代谢综合征的相关性研究
Correlation of Serum Vitamin D Levels with Metabolic Syndrome in the Middle-aged and Elderly
摘要
Abstract
Objective To explore the role of VitD in the pathogenesis of metabolic syndrome(MS) by investigating the correlation of serum vitamin D (VitD) with MS in the middle-aged and elderly.Methods We selected 519 middle-aged and elderly(45 years old or over) outpatients and inpatients with MS treated in Tongling People′s Hospital,Anhui Province between July 2014 and February 2016 as the MS group,and other age-matched 510 community residents without MS underwent physical examination between October and December 2015 as the control group.The measurement of height,weight,blood pressure〔systolic blood pressure(SBP),diastolic blood pressure(DBP)〕,fasting plasma glucose(FPG),total cholesterol (TC),triacylglycerol(TG),high-density lipoprotein cholesterol (HDL-C),low-density lipoprotein cholesterol (LDL-C),apolipoprotein A1(Apo-A1),apolipoprotein B100 (Apo-B100),lipoprotein a〔Lp(a)〕,free fatty acids(FFA),Homocysteine(HCY) serum calcium,phosphorus,VitD,parathyroid hormone(PTH),and fasting insulin(FINS) was performed in all the participants.BMI and homeostasis model assessment of insulin resistance(HOMA-IR) and calcium-phosphorus product were calculated.Results The two groups showed no significant differences in terms of gender,age,height,weight,BMI,TC,TG,HDL-C,LDL-C,FFA,serum calcium and phosphorus,and calcium-phosphorus product(P>0.05).Compared with the control group,MS group had higher levels of SBP,DBP,Apo-B100,Lp(a),HCY,FPG,FINS and HOMA-IR (P<0.05) but lower levels of Apo-A1,VitD and PTH(P<0.05).The distribution of VitD levels in the control group was significantly different from that in the MS group(P<0.05).Gender,levels of HOMA-IR and PTH were obviously associated with the differences in VitD levels in MS patients (P<0.05),while age,height,weight,BMI,levels of SBP,DBP,TC,TG,HDL-C,LDL-C,Apo-A1,Apo-B100,LP(a),FFA,HCY,FPG,FINS,calcium,phosphorus,and value of calcium-phosphorus product were not(P>0.05).VitD levels decreased with the increased proportion of females,rise of BMI,levels of DBP,Apo-B100,HCY,FPG,HOMA-IR and PTH (P<0.05),whereas it grew in straight line with the elevation of levels of SBP and LDL-C(P<0.05).Conclusion MS patients usually have metabolic disorders such as hypertension,hyperglycemia,and hyperlipidemia.Serum VitD levels are correlated with blood pressure,FPG and insulin resistance.Decreased VitD levels might play a role in the pathogenesis of MS.关键词
中年人/老年人/维生素D/代谢综合征XKey words
Middle aged/Aged/Vitamin D/Metabolic syndrome X分类
医药卫生引用本文复制引用
唐吉斌,焦瑞宝,李旭光,刘娜,章文,陈然,孙芸,黄海泉..中老年人血清维生素D水平与代谢综合征的相关性研究[J].中国全科医学,2017,20(16):1955-1960,6.基金项目
铜陵市卫计委基金资助项目(卫科研[2015]7号) （卫科研[2015]7号）
