中国全科医学2017，Vol.20Issue(16)：1973-1977,5.DOI:10.3969/j.issn.1007-9572.2017.16.014
经皮冠状动脉介入治疗术6个月后应用低剂量替格瑞洛的有效性及安全性研究
Efficacy and Safety of Low-dose Ticagrelor in Patients at Six Months after Percutaneous Coronary Intervention
宋敏 1姚朱华 2门剑龙 2曹明英 3黎文婷 2陈颖2
作者信息
- 1. 300070 天津市,天津医科大学研究生院
- 2. 300121 天津市人民医院心内科
- 3. 300052 天津市,天津医科大学总医院医学检验科
- 折叠
摘要
Abstract
Objective To evaluate the efficacy and safety of low-dose ticagrelor in patients at six months after percutaneous coronary intervention(PCI).Methods Nine-five patients underwent postoperative review at 6 months after PCI in Tianjin People′s Hospital between July 2015 and February 2016 were selected as the participants and divided into the ticagrelor group(n=33) and clopidogrel group(n=62) based on the P2Y12 adenosine diphosphate-receptor antagonist type that the postoperatively orally taken drug belongs to.Patients in the ticagrelor group received standard dose of ticagrelor(90 mg,twice daily),and those in the clopidogrel group took clopidogrel(75 mg,once daily) after PCI.At six months after PCI,the ticagrelor group changed to low-dose ticagrelor(45 mg,twice daily),but the clopidogrel group continued to take the same dose of clopidogrel.Both groups were given aspirin(100 mg,once daily).Light transmission aggregometry(LTA) was used to measure the platelet aggregation rate at the time that they completed 1-week,and 3-month administration following the reviewing.Comparisons were made between the two groups′ two measurement results of platelet aggregation rate,major adverse cardiac events(MACE) and adverse reactions occurred during the 6-month follow-up.Results The platelet aggregation rates measured at the time that the patients completed 1-week,and 3-month administration following the reviewing in ticagrelor group were all dramatically lower than those in clopidogrel group(P<0.05).In both groups,little difference was observed between the two measurement results of platelet aggregation rate(P>0.05).The follow-up results showed that,the incidence of MACE was significantly lower in the ticagrelor group than that in the clopidogrel group(P<0.05),but there were no significant difference in the incidence of mild hemorrhage and dyspnea between the two groups(P>0.05).Conclusion Inhibitory effect on platelet aggregation of low-dose ticagrelor administered at 6 months after PCI was significantly stronger than that of clopidogrel.Low-dose ticagrelor can reduce the incidence of ischemic events in the patients after PCI,without increasing the risk of bleeding.关键词
血管成形术,气囊,冠状动脉/替格瑞洛/氯吡格雷/治疗结果Key words
Angioplasty/balloon/coronary/Ticagrelor/Clopidogrel/Treatment outcome分类
医药卫生引用本文复制引用
宋敏,姚朱华,门剑龙,曹明英,黎文婷,陈颖..经皮冠状动脉介入治疗术6个月后应用低剂量替格瑞洛的有效性及安全性研究[J].中国全科医学,2017,20(16):1973-1977,5.
