摘要
Abstract
Objective To evaluate the application value of cardiopulmonary exercise testing in patients with chronic thromboembolic pulmonary hypertension(CTEPH).Methods From January 2009 to October 2013,a total of 72 cases with chronic thromboembolic disease admitted in the People′s Hospital of Henan were enrolled.According to whether it caused pulmonary hypertension,the patients were divided into 2 groups:CTEPH group of 45 cases and chronic thrombosis(CPE) group of 27 cases.And 52 patients with normal cardiopulmonary function in the same period were selected as the control group.All the 3 groups underwent cardiopulmonary exercise testing.The differences of cardiopulmonary function parameters among the three groups were compared and the correlation between the amino-terminal brain natriuretic peptide(NT-proBNP) and cardiopulmonary function parameters were analyzed.Results The plasma concentrations(1 564±1 031)pmol/L of NT-proBNP in the CTEPH group were higher than those in the CPE(595±159)pmol/L and control groups (605±167)pmol/L(both P<0.05).The PetO2,PetCO2,VO2max,VO2/kg,oxygen pulse,anaerobic threshold,VE/VO2,VE/VCO2,VD/VT,VE/VCO2 slope among the 3 groups were compared and the differences were statistically significant(P<0.05).The PetCO2 and VO2/kg in the CPE group were significantly lower than those in the control group.The VE/VO2,VE/VCO2,VD/VT,and VE/VCO2 slope in the CPE group were significantly higher than those in the control group.The PetCO2,VO2max,VO2/kg,oxygen pulse,and anaerobic threshold in the CTEPH group were significantly lower than those in the control and CPE groups.The VE/VO2,VD/VT,and VE/VCO2 slope in the CTEPH group were higher than those in the control and CPE groups.The PetO2,VE/VCO2 in the CTEPH group were higher than those in the control group(P<0.05).Multiple linear regression analysis showed that VO2/kg (β=-0.213,t=-4.436,P<0.001)and the right ventricular internal diameter(β=0.561,t=4.209,P<0.001)were independent influencing factors affecting NT-proBNP levels.Conclusion Cardiopulmonary exercise testing could objectively and quantitatively evaluate the exercise capacity in patients with CTEPH.关键词
肺栓塞/高血压,肺性/心肺运动试验Key words
Pulmonary embolism/Hypertension/pulmonary/Cardiopulmonary exercise testing分类
医药卫生
