中国实用妇科与产科杂志2017，Vol.33Issue(6)：605-608,4.DOI:10.19538/j.fk2017060113
促性腺激素释放激素激动剂治疗子宫内膜异位症反向添加药物疗效比较研究
Comparison of efficacy and safety of different add-back drugs during GnRH-a administration for patients with endometriosis
李雪莹 1肖丽 1黄薇 1冯雪 1傅璟 1阮洁 1陈恒禧 1杨诗源1
作者信息
- 1. 四川大学华西第二医院妇产科,四川成都610041
- 折叠
摘要
Abstract
Objective To compare the efficacy and safety of add-back drug during GnRH-a administration for patients with endometriosis after laparoscopic treatment.Methods Totally 135 women with stage Ⅱ-Ⅳ endometriosis or adenomyoma were randomly assigned into Angeliq group,Tibolone group and Kuntai Capsule group,45 cases in each group.All patients received injection of Diphereline (3.75 mg) on the first day of menstruation,once every 4 weeks for 3 times.They took Angeliq,Tibolone or Kuntai Capsule respectively since the second injection for 8 weeks.Kupperman menopausal index (KMI),serum estradiol (E2) and follicle stimulating hormone (FSH),and ultrasound endometrial thickness were observed and compared.Results At the 4th and 12th week,KMI was comparable among three groups (P＞0.05).KMI at the 12th week was significantly lower than KMI at the 4th week in three groups (P=0.000).Serum E2 and FSH levels,and endometrial thickness had no significant difference among three groups (P＞ 0.05).Conclusion The three kinds of add-back drugs can effectively relieve the low-estrogenic symptoms induced by GnRH-a during medical therapy for endometriosis.关键词
子宫内膜异位症/促性腺激素释放激素激动剂/反向添加治疗Key words
endometriosis/gonadotropin-releasing hormone agonist/add-back therapy分类
医药卫生引用本文复制引用
李雪莹,肖丽,黄薇,冯雪,傅璟,阮洁,陈恒禧,杨诗源..促性腺激素释放激素激动剂治疗子宫内膜异位症反向添加药物疗效比较研究[J].中国实用妇科与产科杂志,2017,33(6):605-608,4.
